by Alpha | Nov 10, 2016 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
2. CHK:$CHK – upgraded to Hold at Jefferies
10. NOC:$NOC upgraded to Overweight at Barclays – PT raise $270 from $230
12. PCLN:$PCLN upgraded to Buy at Stifel Nicolaus – PT raise $1.9k from $1.65
DOWNGRADES
8. MS, VRX:Rodman downgrades $vrx to neutral. $ms cuts PT from $42 to $25.
11. VRX:$VRX downgraded to Neutral at Rodman & Renshaw – PT cut $23 from $81, maintains Overweight rating at Morgan Stanley – PT cut $25 from $42
EARNINGS
Trending Social Alerts
2. ANTH:$ANTH Blisibimod CHABLIS-SC1 Phase 3 Study Did Not Achieve the Primary Endpoint in Patients With Active Systemic Lupus Erythematosus #Fail
4. IBB:$XBI up 2.7% $IBB up 1.93% in pm
5. SODA:$SODA Reports Q3 EPS $0.69 vs. Est. $0.23, Rev. $124.2M vs. Est. $115M – double digit growth 🙂
6. SGEN:$SGEN Receives FDA Breakthrough Therapy Designation for ADCETRIS® in Mycosis Fungoides & Primary Cutaneous Anaplastic Large Cell Lymphoma
7. MNKD:.@AdamSinger Neither do I, but it’s a bizarre announcement. Does $MNKD have compromising photos or similar?
8. CELG:@tgtxdough $IBB $CELG coiled spring of money flow may need to shift back over to biotech.
9. KSS:Kohl’s Reports Q3 Adj. EPS $0.80 vs $0.70 Est., Sales $4.327B vs $4.33B Est. $KSS
11. TUBE:$TUBE Adobe $ADBE to acquire TubeMogul for $14/sh
Trending News Headlines
1. Six thoughts on President Trump and the durability of the biotech stock rally
Investors have convinced themselves that President Donald Trump is going to make drug stocks great again. Will it last?
2. Bristol-Myers hands over $100M in cash for a new fibrosis drug, beefing up NASH focus
It’s not all checkpoints all the time at Bristol-Myers Squibb. The big biotech has been ramping up an ambitious effort in fibrosis and NASH and this morning it’s taking the wraps off another deal in the field, paying $100 million to Japan’s Nitto Denko for an early-stage drug candidate that
3. Opdivo (nivolumab) Demonstrates Overall Survival Benefit in Patients With Unresectable Advanced or Recurrent Gastric Cancer in Phase 3 Study
Opdivo is the first and only Immuno-Oncology agent to demonstrate overall survival advantage in patients with unresectable advanced or recurrent gastric cancer refractory to, or intolerant of, standard therapy Bristol-Myers Squibb Company (NYSE:BMY) announced today that ONO-4538-12, a Phase 3, randomized, double-blind clinical trial evaluating the efficacy and safety of Opdivo (nivolumab) in patients with unresectable advanced or recurrent gastric cancer refractory to, or intolerant of, standard therapy, met its primary endpoint of overall survival (OS). Ono Pharmaceutical Co. Ltd. of Japan , Bristol-Myers Squibb’s development partner for Opdivo , conducted the ONO-4538-12 trial. The companies will work with investigators on the future presentation of the study results. Fouad Namouni, M.D., head of development, Oncology, Bristol-Myers Squibb, commented, “Patients with advanced or recurrent gastric cancer generally have a poor prognosis, and there are currently no standard-of-care
4. Halozyme Announces Broad Clinical Collaboration Agreement To Evaluate PEGPH20 And Tecentriq In Up To Eight Tumor Types
Phase 1b/2 studies will evaluate Halozyme’s investigational drug, PEGPH20 with Genentech’s anti-PDL1 Tecentriq® (atezolizumab) Halozyme Therapeutics, Inc. (NASDAQ: HALO), an oncology biotech developing novel oncology and drug-delivery therapies, and Genentech, a member of the Roche Group , today announced an agreement to collaborate on clinical studies evaluating up to eight different tumor types beginning in 2017. The first study will be a Phase 1b/2 open-label, multi-arm randomized global study, led by Genentech to evaluate their cancer immunotherapy Tecentriq® (atezolizumab), an anti-PD-L1 monoclonal antibody, in combination with Halozyme’s investigational drug, PEGPH20 in six tumor types. Halozyme will supply drug only for the Genentech study. This study will have an initial focus on gastrointestinal malignancies, including pancreatic and gastric cancers. The second study will be a Phase 1b open-label randomized study led by Halozyme to assess Tecentriq in combination with PEGPH20
5. Andy Biotech on Twitter
“$AZN discontinues its Anti-CD19 in DLBCL and Anti-ANG2 in solid tumors. $JUNO $KITE $SGEN $XNCR”
6. Katy Perry Ditches Alibaba’s Concert After Anti-Trump Tweets
Pop star Katy Perry has pulled out of a star-studded extravaganza put on by China’s largest online retailer.
7. Tesla’s own numbers show Autopilot has higher crash rate than human drivers
A couple of weeks ago, I wrote about Tesla’s claim that its Autopilot driver-assistance software is safer than a human driver. After a fatal Autopilot crash last May, the company said the death was the first in 130 million miles of Autopilot driving—and noted that, “among all…
8. AstraZeneca sees big healthcare changes under Trump
Drugmaker AstraZeneca (AZN.L) expects major U.S. healthcare changes after Donald Trump’s election victory but its chief executive warned on Thursday that pricing pressures in the world’s biggest drugs market would not go away.
9. IEA sees global market awash with oil in 2017 if no OPEC cut
The oil market risks running another surplus in 2017 without an output cut from OPEC, as producers around the globe ramp up supply and demand growth falters, the International Energy Agency said on Thursday.
10. U.S. should have joined China-led infrastructure bank: Trump adviser
A top adviser of U.S. President-elect Donald Trump lashed out at the Obama administration for failing to embrace the China-led Asian Infrastructure Investment Bank (AIIB), suggesting a possible policy shift when Trump takes office in January.
Technology News
Check out which companies are making headlines before the bell: Kohl’s – The retailer reported adjusted quarterly profit of 80 cents per share, 10 cents a share above forecasts. Revenue was very slightly above estimates. Same-store sales did fall by 1.7 percent, but that drop was in line with analysts’ projections.
by Alpha | Nov 9, 2016 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
2. AGTC:$AGTC upgraded to Buy From Neutral by Roth Capital. PT $15
8. DEPO:$DEPO upgraded to Buy From Neutral by Mizuho
DOWNGRADES
EARNINGS
Trending Social Alerts
1. KITE:$KITE — KTE-C19 BLA to be submitted in Q1 ’17.
2. INFI:$BMY and $INFI Announce Clinical Collaboration to Evaluate Opdivo in Combination with IPI-549 in Advanced Solid Tumors
4. CELG:$CELG bidding 112 up 4 bucks $IBB 277 bid up 15. $GILD up 2
7. IBB:massive victory for #biotech last $IBB +12 already pre market
8. XBI:$XBI up 6%!
10. ARIA:In other news last night… $ARIA gets subpoena from US Attorney MA related to patient support programs, $ARWR ph2 HepB study clinical hold.
11. HCA:holy cow. $HCA down 16%
Trending News Headlines
1. Biotech Stocks Surge on Trump Victory (XBI) (IBB)
Biotech stocks are surging in pre-open trade on Trump Win. Trump is viewed as potentially less onerous than Clinton on drug pricing.XBI (NYSE: XBI) is up…
2. The Associated Press on Twitter
“BREAKING: Donald Trump is elected president of the United States.”
3. dough on Twitter
“BMO TRUMP no more obamacare = positive for major pharma $MRK $BMY $PFE $CELG $GILD”
4. Kite Pharma Reports Third Quarter 2016 Financial Results | Business Wire
Kite Pharma, Inc. (Nasdaq: KITE), a clinical-stage biopharmaceutical company focused on developing engineered autologous cell therapy (eACT™) pr
5. ASH Abstract Confirms Positive Outlook For Actinium’s Actimab-A
AML, Actimab-A, ATNM, ASH
6. Hospital Stocks Slammed on Trump Victory (HCA) (THC) (UHS)
Hospital stocks are bid sharply lower on a Trump victory. Trump is seen overturning Obamacare, which would be seen as negative for the hospitalsHCA Holdings (NYSE: HCA)…
7. Eric Scott Hunsader on Twitter
“Brexit vs Trump $ES_F $SPY”
Technology News
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by Alpha | Nov 8, 2016 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
5. RACE:$RACE upgraded to Hold at Evercore ISI Group
DOWNGRADES
2. CEMP:$CEMP — Andy Berens from MS downgrades to underweight from overweight, PT to $5 from $35.
4. GS:$GS downgraded to Neutral at Citigroup
EARNINGS
Trending Social Alerts
2. VRX:Valeant Pharmaceuticals Q4 earnings Adj EPS $1.55 Revenue $2.48 bln $VRX
4. OREX:$OREX $VRX .. Orexigen Therapeutics Announces Commercialization and Distributorship Agreement with Valeant for Contrave®
Trending News Headlines
1. Andy Biotech on Twitter
“$VRX cuts EPS guidance by >20%, driven by issues in every segment of business…”
2. Tesla acquires Grohmann engineering to boost production
Tesla just announced that it will acquire Germany’s Grohmann Engineering, in a deal that will see the global engineering leader become Tesla’s new Advanced..
3. Valeant Goes Back to Slashing Guidance
Valeant returned to slashing its annual outlook, signaling the pharmaceutical company is still hemorrhaging from missteps over the past year despite efforts to remake its business.
4. Leaked documents shed light on the defunct pharmacy that brought Valeant to its knees
Valeant had a sales plan dubbed the “Philidor strategy” to use the pharmacy and increase the volume of shipments for two of its drugs, Solodyn and Jublia.
5. howardlindzon on Twitter
“Why Twitter must be saved …from @benthompson $twtr $fb (sadly mostly from itself)”
6. Tesla to buy Grohmann Engineering to ramp up automated manufacturing
Electric carmaker Tesla Motors Inc (TSLA.O) said on Tuesday it would buy German firm Grohmann Engineering to improve its automated manufacturing systems.
7. A watershed moment for marijuana legalization
Referenda on marijuana legalization in five states may turn out to be a milestone in the struggle against drug prohibition.
8. The Priceline Group (PCLN) PT Raised to $1800 at Jefferies
Jefferies analyst Brian Fitzgerald reiterated a Buy rating and raised his price target on The Priceline Group (NASDAQ: PCLN) to $1,800.00 (from $1,700.00).Fitzgerald commented, “PCLN reported another solid…
Technology News
by Alpha | Nov 7, 2016 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
2. BIIB:$BIIB upgraded to Overweight at PiperJaffray
7. CYBR:$CYBR upgraded to Outperform at Imperial Capital – PT $55
14. TWX:$TWX upgraded to Outperform at Credit Suisse – PT $107.50
DOWNGRADES
5. GPRO:$GPRO downgraded to Underperform at Bank of America
6. TEVA:$TEVA downgraded to Neutral at Bank of America
EARNINGS
Trending Social Alerts
3. NILE:$NILE -10% on Friday; acquired by Bain at $40.75 on Monday. The game is hard
4. N:$N Halted, news pending
6. CXRX:Concordia misses estimates by wide margin $0.69 vs $1.04 expected Will no longer provide financial forecasts $CXRX $CXR.TO
Trending News Headlines
1. Cempra antibiotic approval still in doubt even with positive fda panel vote
By a slim 7-6 margin, experts convened by the FDA decided the benefits of solithromycin outweighed its potential safety problems in treating patients with community-acquired bacterial pneumonia.
2. MGM Resorts (MGM) Tops Q3 EPS Views; MGM China Revenue Sank 6%
MGM Resorts (NYSE: MGM) reported Q3 EPS of $0.53, $0.42 better than the analyst estimate of $0.11. Revenue for the quarter came in at $2.52 billion versus the consensus estimate of $2.38…
3. Banks Passed Up Uber Share Sale on Lack of Data
The potential fees and reputation boost that could come from working on Uber Technologies Inc.’s initial public offering are the stuff of bankers’ dreams.
4. Biotech portfolio updates – ESMO 2016, Exelixis, Abeona, Esperion and Seattle Genetics | Open Reading Frame
After a two-month break here is a recap of key highlights from the September/October time frame. On the menu today: PD-1 controversies at ESMO 2016, Exelixis’ ( EXEL ) launch in renal cancer, gene therapy data from Abeona ( ABEO ), long awaited update from Esperion ( ESPR ) and a positive surprise from Seattle Genetics ( SGEN ).
5. FDA panel, by a whisker, votes yes on Cempra’s antibiotic | FierceBiotech
An FDA panel has voted 7-6 that Cempra’s new antibiotic solithromycin should be recommended for U.S. regulatory approval–coming days after its shares plummeted by 40% on safety fears.
6. Bain Capital, Bow Street-Led Investor Group to Acquire Blue Nile (NILE) for $40.75/Share
Leading online jeweler Blue Nile (Nasdaq: NILE), announced that it has entered into a definitive agreement to be acquired by an Investor Group comprised of funds managed by…
7. Meg Tirrell on Twitter
“Piper’s Schimmer lists collusion focus potentially shifting to MS as risk in $BIIB upgrade”
8. Windstream (WIN), EarthLink (ELNK) Enter $1.1B Merger Agreement
Windstream Holdings, Inc. (Nasdaq: WIN) and EarthLink Holdings Corp. (Nasdaq: ELNK) announced that their boards of directors have unanimously approved a definitive merger…
Technology News
by Alpha | Nov 4, 2016 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
8. JUNO:$JUNO Upgraded to Neutral at BTIG Research
10. TRUE:$TRUE upgraded at Stephens, Craig, and Loop Capital. 3 upgrades
DOWNGRADES
8. FIT:$FIT downgraded to Equal-Weight at Barclays – PT cut $10 from $24, downgraded to Neutral at Wedbush – PT cut $10 from $18
13. TEVA:$TEVA downgraded to Hold at HSBC
15. WFM:$WFM downgraded to Underperform at Bank of America
EARNINGS
Trending Social Alerts
Trending News Headlines
1. Apple is taking 104% of the profits in the entire smartphone industry
It sounds impossible — but no other company in the smartphone business comes even remotely close to Apple’s success.
2. Exclusive: Saudis threaten to raise oil output again as sparring with Iran returns
By Rania El Gamal and Alex Lawler DUBAI/LONDON (Reuters) – Old disputes between Saudi Arabia and rival Iran resurfaced at a meeting of OPEC experts last week, with Riyadh threatening to raise…
3. Skyworks Solutions (SWKS) PT, Estimates Lifted at Needham & Company; Consistent Execution
Needham & Company analyst N. Quinn Bolton reiterated a Buy rating and boosted his price target on Skyworks Solutions (NASDAQ: SWKS) to $84.00 (from $73.00) following results. The firm notes consistent execution and…
4. Payrolls in U.S. Rose by 161,000 in October as Wages Accelerate
U.S. jobs continued to gain at a steady pace in October and wage gains accelerated, signs that the labor market and economy made steady progress at the start of the fourth quarter.
Technology News
by Alpha | Nov 3, 2016 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
6. RIG:$RIG upgraded to Buy at Canaccord Genuity
7. X:$X upgraded to Neutral at Bank of America
DOWNGRADES
2. EL:$EL downgraded to Underperform at CLSA
3. FIT:BofA does the ol’ buy-to-sell downgrade on $FIT. @CNBC
7. SKX:$SKX downgraded to Neutral at B. Riley
EARNINGS
Trending Social Alerts
1. FIT:LIVE NOW: $FB’s slowing growth, $FIT’s flop and a shake-up at $WFM – Watch our stocks preview…
4. GBPUSD:Govt loses! $GBPUSD surging
7. CWEI:@Orangeman1992 I’ll tell ya one thing : $CWEI priced for much higher oil , not a return < $40 . That record says a lot
8. DDD:3D Systems Reports Q3 Adj. EPS $0.14 vs $0.09 Est., Sales $156.4M vs $160M Est. $DDD
Trending News Headlines
1. Paper: Lentiglobin Gene Therapy for Transfusion-Dependent β-Thalassemia: Update from the Northstar Hgb-204 Phase 1/2 Clinical Study
Alexis A. Thompson, MD, MPH 1 , Janet Kwiatkowski, MD 2 , John Rasko, MBBS, PhD 3 , Suradej Hongeng, MD 4 * , Gary J. Schiller, MD 5 , Usanarat Anurathapan, MD 4 * , Marina Cavazzana, MD, PhD 6 , P. Joy Ho 3 , Christof von Kalle, MD 7 * , Morris Kletzel, MD, FAAP, MBA 8 , Philippe Leboulch, MD 4,9,10 * , Elliott Vichinsky, MD 11 , Alexandria Petrusich 12 * , Mohammed Asmal, MD, PhD 12 * and Mark C. Walters, MD 13
2. While 5,000 Wells Fargo Employees Got Fired, Their Bosses Thrived
After Wells Fargo & Co. executive John Sotoodeh handed off more than a hundred branches in Southern California to a colleague in 2009, problems surfaced quickly.
3. Paper: A Phase 1 Study of TTI-621, a Novel Immune Checkpoint Inhibitor Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies
Stephen Ansell, MD, PhD 1 , Robert W Chen, MD 2 , Ian W. Flinn, MD, PhD 3 , Michael B. Maris, MD 4 , Owen A. O’Connor, MD, PhD 5 , Lisa DS Johnson, PhD 6 * , Meghan Irwin 6 * , Penka S. Petrova, PhD 6 * , Robert A. Uger, PhD 7 * and Eric L Sievers, MD 6
4. Hillary Clinton Still Leads a Tighter Race, Times/CBS News Poll Shows
Most voters say that their minds are made up and that late revelations about Mrs. Clinton and Donald J. Trump made no significant difference to them.
5. Wells Fargo Confirms SEC Probe Into Its Sales Practices
Wells Fargo confirmed that the Securities and Exchange Commission is one of the agencies probing matters related to its sales practices.
6. Inside Wells Fargo, workers say the mood is grim
Wells Fargo workers tell CNNMoney they are angry at the bank for shifting blame on them and remain scared of being retaliated against for speaking up about bad behavior.
7. New Goldman ETF tracks popular hedge fund stock bets
Goldman Sachs Group Inc has launched a new exchange traded fund that mimics the most popular stock bets made by hedge funds, the bank said on Thursday.
8. Trillium Therapeutics Announces Investor and Scientific Presentation Schedule for Remainder of 2016
TORONTO, Nov. 3, 2016 — Trillium Therapeutics Inc. (NASDAQ: TRIL; TSX: TR) , a clinical stage immuno-oncology company developing innovative therapies for the treatment of cancer, is scheduled to present an update on the company’s programs and progress at several upcoming conferences in 2016. Investor Conference: Oppenheimer Life Sciences Summit Attendee: Niclas Stiernholm, PhD, Trillium Chief Executive Officer Date and Time: Nov. 29, 2016 Location: Sofitel Hotel, New York City Scientific Conferences: The Society for Immunotherapy of Cancer (SITC) 31st Annual Meeting Presenter: Lisa Johnson, PhD, Trillium Research Scientist Title: CD47 is Overexpressed on Merkel Cell Carcinoma and a Target for SIRPαFc Therapy Date and Time: Nov. 11, 2016, 12:15 – 1:30 p.m. and 6:15 – 7:30 p.m. ET Location: Gaylord National Hotel Convention Center, National Harbor, MD American Society of Hematology (ASH) 58th Annual Meeting Presenter: Stephen Ansell, MD, Division of Hematology,
Technology News