by Alpha | Jul 7, 2017 | Pre-Market
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1. DGLY:$DGLY ‘significant’ patent win against $AAXN
2. BMRN:$BMRN updated data ongoing BMN270 Hemophilia A study including preliminary 4E13 vg/kg cohort data in 3 of 6 patients. I
3. BGNE:$BGNE few know Chinese drug market/regulatory work than I since I was a CEO of a small pharm and VP of a big pharm since 03-07 in China.
4. ARNA:$ARNA upgraded to outperform at JMP. $27 PT
5. CLVS:$CLVS initiated at Buy at Gabelli. PT $125
Trending News Headlines
1. O’Connor resigns as CEO of Advaxis with immediate effect | FierceBiotech
Daniel O’Connor has resigned as CEO of Advaxis. The cancer immunotherapy biotech has put CBO Tony Lombardo in charge while it searches for a permanent successor to O’Connor.
2. Fox Business Network Suspends Charles Payne Amid Misconduct Inquiry
Mr. Payne’s suspension came after The National Enquirer published a report in which he acknowledged an extramarital affair with a former CNN and Fox News contributor.
Technology News
The latest analysis from Consumer Intelligence Research Partners CIRP pegs total Prime membership at million which is up percent from the quarter and double from two years ago.
While quarterly growth is slowing Amazon is still adding a substantial amount of new Prime members who end up spending per year on average with the site compared to for.
The online retail giant continuously adds new perks for members to induce more customers to sign up free shipping cloud storage streaming media and access to exclusive deals are just some of the benefits.
reducing our costs and continuing our revenue growth on our path to profitability and in control of independent future Alexander Ljung the chief executive and wrote in a blog post.
But it also faced pressure from the record labels to sign licensing deals and develop a paid subscription model to compete with Spotify and Apple Music.
In its latest financial report filed with British regulators late last year SoundCloud said that it had enough cash to meet its obligations only through September in March the company secured a million line of credit.
And in May Oculus head of computer vision Dov Katz was arrested for soliciting sex from an undercover police officer he thought was a girl.
And much like in video gaming where the use of is still relatively common despite the backlash against it it almost exclusively women who are hired as concierges at conferences and conventions encouraging people to come try on VR headsets.
After receiving several member complaints that the presence of Upload executives within the group violated the sanctity of the space we voted to remove said executives from the group Young and Duong told BuzzFeed News via email when asked in how they were addressing the fact that some members of Women in VR felt uncomfortable airing some of their issues with Upload in light of Duong friendship with Will Mason and his previous position on the board.
SoundCloud is cutting about percent of its staff in a move the digital music service says will give it a better financial footing to compete against larger rivals Spotify and Apple Inc.
SoundCloud has about million listeners who are drawn to its expansive library of songs dance mixes podcasts and other content uploaded by artists ranging from established stars to bedroom DJs.
While consumer adoption of streaming services has led the largest record labels to see sustained sales growth for the first time since the glory days of the CD the companies delivering the music online have struggled to make money.
Venture capitalists need to adopt formal policies to protect startup founders from sexual harassment assault and discrimination throughout the fundraising process.
We hope to see all VC firms draw from this template to formalize their own binding policies establish them with urgency and consistently with ejecting or punishing staff that violate them.
For more on how firms can ensure fair enforcement and how this cultural shift towards decency can avoid causing a chilling effect on fundraising for startups check out TechCrunch editor Josh accompanying The need for harassment policy Constine also coordinated compiled and edited the information contributed to this template.
Today it takes complex software and a specific skillset to create compelling VR and AR experiences.
So we developed Blocks a VR app for the HTC Vive and Oculus Rift that lets you easily create beautiful objects in no time.
already seen amazing creations and use cases from modelers artists developers and even people with no modeling experience at from a robot that could star in a game to a skyline meant as a backdrop for a Tilt Brush sketch to some cacti made just for fun.
Microsoft announced a major reorganization on Wednesday that will include thousands of layoffs largely in sales.
Reports from last week suggested this was going to happen and that Microsoft was going to specifically focus on how it sells its product Azure.
WATCH Microsoft Surface Pro is here and it really expensive Clarification An earlier version of this story misstated the number of employees to suffer layoffs.
The reach of the online advertising campaign was such that potential Labour voters in marginal constituencies who verbally raised concerns about the NHS to a party activist on the doorstep would find their Facebook feed targeted with adverts warning about the state of the health service the following day.
The party wasted money advertising to voters in constituencies such as Labour MP Dennis Skinner Bolsover seat where the sources said Conservative HQ wrongly thought they had a realistic chance of winning in part due to a reliance on data provided by the US election campaigner Jim Messina.
Tory adverts obtained by BuzzFeed News also show how the party increasingly put online resources into fighting two regional battles holding off a Liberal Democrat comeback in southwest England and supporting Ruth Davidson Scottish Conservatives in key target seats.
Read comments from top tech and industry leaders.
by Alpha | Jul 6, 2017 | Pre-Market
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3. ORLY:$ORLY downgraded both @ CS & MS to Neutral
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1. LB:$LB -7.4% … another dead cat retail bounce gets slammed back down
3. BGNE:$BGNE deal terms shockingly good – Baird. Raises PT to $58 from $44
Trending News Headlines
1. Amazon, Dish and a Shared Vision of a Wireless ‘Internet of Things’
For years, Dish Network has sought out deals and partnerships with just about every major telecom company. Now, the satellite TV company is turning to the tech world and a new—and somewhat surprising—potential partner has emerged: Amazon.com.
2. Shire submits investigational New Drug Application to FDA for Gene Therapy candidate SHP654 for treatment of Hemophilia A
3. Celgene Corporation Enters Into Global Strategic Immuno-Oncology Collaboration with BeiGene to Advance PD-1 Inhibitor Program for Solid Tumor Cancers (NASDAQ:CELG)
Celgene accelerates its immuno-oncology strategy in solid tumors with acquisition of worldwide rights, rest of world outside Asia, to BeiGene’s PD-1 in…
4. dough on Twitter
“BMO – $CELG PD-1 Acquisition Vaults CELG Into the IO Fray $BGNE”
5. QVC buying longtime rival Home Shopping Network in deal valued at $2.1 billion
QVC just made a deal to buy its biggest rival, the Home Shopping Network.
Technology News
Since we used actual TechCrunch Disrupt transcripts as the basis for the audio files we redacted the dialogue for any startup specifics and standardized the clips to control for variations in quality and stage.
Armed with the knowledge that promotion has advantages over prevention informed entrepreneurs can recognize question orientation and frame their responses to benefit their startups.
By posing a balance of promotion and prevention questions to men and women investors grant all startups an equal chance to display their worthiness and may even improve their own decision making in the process.
The explosive allegations have brought the venture capital firm Caldbeck to the brink of collapse and have exposed the broader problem that men with wealth and influence are using their position to prey on women who are seeking funding and advice to build their careers and companies.
Alleged predatory behavior by a prominent venture capitalist has struck a cord on social media where women who have come forward have found deep support suggesting that the cone of silence that once protected perpetrators has cracked if not shattered.
I hope the industry continues to support women who speak up and shun men who do these things said entrepreneur Sarah Kunst who when discussing a possible job at Startups in received a message from McClure on Twitter that said in part I was getting confused figuring out whether to hire you or hit on you.
I had doubts publishing this but after talking to Sarah it is clear to me now that I just sit silently and trust that behavior will stop or that we can just file his misconduct under being This is about protecting other women who might otherwise be subjected to his future unwanted sexual advances.
After the meeting Khailee Dave and a few others including two other females decided to come over to my apartment to brainstorm about new Growth Distribution Accelerator Cerebro later rebranded as Distro Dojo and also a hashtag for MaGIC the organization that I was leading.
Separately they should survey their own partners associates and staff members on what behaviors they consider acceptable vs crossing boundaries and ask for admission of any wrong doings as a step to create awareness and as a reminder that there are severe consequences if they are caught violating company policy and abusing their position.
Today thrilled to announce our next phase the opening of first ever international AI research office in Edmonton Canada in close collaboration with the University of Alberta UAlberta.
We publish in major international journals including three Nature papers in the past two years while many of our team maintain professorships and supervise students at Cambridge Oxford Imperial College London as well as MIT and beyond.
In the UK we feel helped played an important role in encouraging and supporting the AI community to flourish from and universities to new organisations like the Turing Institute and we hope that we can contribute to the success of pioneering centres of research too.
China latest maneuvre in a sweeping crackdown on internet content has sent a chill through a diverse community of filmmakers bloggers media and educators who fear their sites could be shut down as Beijing tightens control.
On Friday an industry association circulated new regulations that at least two auditors will with immediate effect be required to check all audiovisual content posted online from films to micro movies documentaries sports educational material and animation to ensure they adhere to core socialist values.
The rules which affect social media giants like Weibo Corp as well as small platforms that have thrived in China buzzing creative online space are the latest step toughening oversight ahead of the Communist Party Congress later this year when President Xi Jinping is expected to consolidate power.
Read comments from top tech and industry leaders.
You are expected to be the communicator and the nurturer whose primary function is to get everyone on the same page often at your own expense but you will be perceived as a serial compromiser with no backbone if you do that are supposed to be decisive but if you are you will be punished for not getting enough input from other people or being arrogant for not yourself.
clear that Sinha credits McClure with some of her early success and I believe her willingness to speak up on his behalf is coming from a place of bad faith.
But it adds little to the conversation because it has no bearing on the core problem which is that McClure harassed women who are not Sinha and this sort of behavior is enabled systemically in the tech industry.
ET Vantiv appeared to ward off Morgan Chase in the pursuit of payments processor Group PLC saying it had cinched a billion takeover deal.
The proposed combination if successful would create a payments processing giant with a combined market value of more than billion.
The tussle continues despite the fact that some of the desired data including whether individuals have voted in the past decade is set to become part of the public record separate from this situation.
Kansas Secretary of State Kris Kobach the commission vice chair has said SSNs could be used to determine how many people who are dead remain on voter rolls and whether they have recently voted for instance.
And EPIC explained that the Commission had already committed two egregious security directing state election officials to send voter records to an unsecure web site and proposing to publish partial SSNs that would enable identity theft and financial fraud.
by Alpha | Jun 29, 2017 | Pre-Market
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1. RAD:$RAD rips higher on agreement with WBA
Trending News Headlines
1. Bitcoin Has Become So Volatile It Looks Like an ETF on Steroids
There’s volatility. And then there’s bitcoin volatility.
2. Walgreens scraps Rite Aid deal, and instead will buy some stores in $5.18 billion deal
Walgreens Boots Alliance canceled its previous merger deal with Rite Aid and replaced it with a new agreement.
3. Walgreens Scraps Rite Aid Takeover, Will Purchase 2,186 Stores
Walgreens Boots Alliance Inc. scrapped its deal to purchase Rite Aid Corp. that had been under Federal Trade Commission scrutiny and will instead buy 2,186 of the rival drugstore chain’s stores for $5.18 billion.
4. Amazon is bringing back ‘Prime Day’ on July 11 — but deals start sooner
Tuesday, July 11 is the third annual Amazon Prime Day. With two years of experience under its belt, this Prime Day is going to be its biggest yet.
5. 21st Century Fox Takeover of Sky Faces Further U.K. Inquiry
The announcement is a blow for Rupert Murdoch and other executives at 21st Century Fox who have long sought to add Sky to their stable of businesses.
6. Fox’s Bid for Sky Set for More U.K. Scrutiny
The U.K. government said it was likely to require further scrutiny of 21st Century Fox’s $15.1 billion bid to buy the 61% of British TV giant Sky it doesn’t already own.
7. UK regulator says it finds 21st Century Fox bid for Sky raises public interest concerns
The British government said Thursday that it believes there are no issues with broadcasting standards regarding the potential 21st Century Fox takeover of Sky.
Technology News
Added more info on the wiper command comparative screenshots of the two keys that visually confirms finding and why the MBR copy routine make sense.
Yesterday we provided a preliminary analysis where we demonstrated that the June version of Petya leveraged SMB exploits ETERNALBLUE and ETERNALROMANCE.
Conclusion We believe the ransomware was in fact a lure to control the media narrative especially after the WannaCry incidents to attract the attention on some mysterious hacker group rather than a national state attacker like we have seen in the past in cases that involved wipers such as Shamoon.
Two weeks ago the United States through the Department of Homeland Security said it had evidence North Korea was responsible for a wave of attacks in May using ransomware called WannaCry that shut down hospitals rail traffic and production lines.
For the American spy agency which has invested billions of dollars developing an arsenal of weapons that have been used against the Iranian nuclear program North missile launches and Islamic State militants what is unfolding across the world amounts to a digital nightmare.
North Korea Russia China Iran or ISIS almost all of the flash points out there now involve a cyber element Leon Panetta the former defense secretary and Central Intelligence Agency chief said in a recent interview before the weapons were turned against American interests.
ROCKET CENTER A few years ago Sean Bridges lived with his mother Linda in Wiley Ford Their only income was her monthly Social Security disability check.
Continue reading the main story This jobs approach matters at a time when there is a push to improve the circumstances of those left behind in the American economy many of whom voted for President Trump.
desperately need to revive a second route to the middle class for people without college degrees as manufacturing once was said Robert Reich a labor secretary in the Clinton administration who is now a professor at the University of California Berkeley.
ROCKET CENTER A few years ago Sean Bridges lived with his mother Linda in Wiley Ford Their only income was her monthly Social Security disability check.
Continue reading the main story This jobs approach matters at a time when there is a push to improve the circumstances of those left behind in the American economy many of whom voted for President Trump.
desperately need to revive a second route to the middle class for people without college degrees as manufacturing once was said Robert Reich a labor secretary in the Clinton administration who is now a professor at the University of California Berkeley.
Rather than just encrypting infected hard drives and demanding in bitcoin for the decryption key in some cases it simply wiped machines on the same network deleting a victim computer master boot record which tells it how to load its operating system.
Security firm FireEye has tied those attackers to Russia based in part on analysis of an openly accessible command and control server it used that contained documents explaining how to use a piece of malware it had planted on target computers.
Aside from the MeDoc update trick Petya also spreads within networks using a variety of automated tools that exploited obscure Microsoft protocols like Windows Management Instrumentation PSExec and Server Message Block all hallmarks of sophistication.
Employees at a store in Kiev Ukraine read a ransomware demand for in bitcoin to free files encrypted by the Petya software virus.
Vincent via Getty Images The Petya cyberattack that has now struck computers in at least countries can be traced to a Ukrainian company tax accounting software Microsoft says.
That connection was the subject of speculation Tuesday but Microsoft now says it has evidence that a few active infections of the ransomware initially started from the legitimate MEDoc updater process.
Perhaps even worse the court ruled that before Google can modify the order it has to prove that the injunction violates the laws of another nation thus shifting the burdent of proof from the plaintiff to a.
The ruling largely sidesteps the question of whether such a global order would violate foreign law or intrude on Internet free speech rights.
The Equustek decision is part of a troubling trend around the world of courts and other governmental bodies ordering that content be removed from the entirety of the Internet not just in that country locale.
In a decision the court agreed a British Columbia judge had the power to issue an injunction forcing Google to scrub search results about pirated products not just in Canada but everywhere else in the world too.
Those siding with Google including civil liberties groups had warned that allowing the injunction would harm free speech setting a precedent to let any judge anywhere order a global ban on what appears on search engines.
A spokesperson for Music Canada which represents major recording labels said in a statement that the new worldwide injunction will be a vital remedy to address illegal online activities and enforce the rights of.
The reason is that Facebook deletes curses slurs calls for violence and several other types of attacks only when they are directed at on race sex gender identity religious affiliation national origin ethnicity sexual orientation and serious.
Facebook has since dropped the provision and revised its definition of terrorism to include nongovernmental organizations that carry out premeditated violence achieve a political religious or ideological aim according to a person familiar with the rules.
Kate Klonick a candidate at Yale Law School who has spent two years studying censorship operations at tech companies said the photo had likely been deleted by Facebook thousands of times for violating its ban on nudity.
A New Zealand Department of Internal Affairs spokesman denied their system discriminated against any specific set of individuals.
He added that up to of photos submitted online are rejected for a variety of reasons most commonly shadows on the face which the software interprets as closed eyes.
Lee currently attending university in Melbourne Australia eventually gave up and went to a local post office to get some passport photos taken.
by Alpha | Jun 27, 2017 | Pre-Market
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1. MRK:Wow! $MRK CETPi anacetrapib CVOT met its primary endpoint, significantly reducing major coronary events. Full data at #ESC17. -> $ESPR
3. ESPR:Stifel $ESPR FDA Oks Zetia Combo via 505 – We Expect Most Zetia Patients to Convert. TP to $60. From 45
4. XENE:$XENE halt, news pending
6. P:Pandora $P halted for news. Could be CEO departure news
7. TMUS:Not so pretty in pink? T-Mobile may be odd carrier out if Sprint does deal with Charter & Comcast. $TMUS down 3% #premarket. $S $CHTR $CMCSA
Trending News Headlines
1. Google Gets Record $2.7 Billion EU Fine for Skewing Searches
Google lost its biggest regulatory battle yet, getting a record 2.4 billion-euro ($2.7 billion) fine from European Union enforcers who say the search-engine giant skewed results in its favor to thwart smaller shopping search services.
2. Google Fined €2.42 Billion by EU for Skewing Search Results
Google was fined €2.42 billion ($2.7 billion) by European Union regulators for skewing search results in its own favor to boost its shopping search service.
3. The IMF’s recommendations for boosting US growth look a lot like the Trump agenda
US economy needs tax reform, infrastructure spending and better regulations to make sure benefits hit everyone, according to the IMF.
4. IMF Cuts U.S. Outlook, Calls Trump’s Growth Target Unrealistic
The International Monetary Fund cut its outlook for the American economy and said the U.S. probably won’t meet President Donald Trump’s target of 3 percent annual growth, Bloomberg News reports. Developing…
5. Google’s record-breaking antitrust fine is sending the stock slipping
The European Commission has fined Google $2.7 billion over unfair favoring of Google’s own shopping search results over competitors.
6. Merck Provides Update on REVEAL Outcomes Study of Anacetrapib
Merck , known as MSD outside of the United States and Canada, today announced that the REVEAL outcomes study of anacetrapib met its primary endpoint, significantly reducing major coronary events compared to placebo in patients at risk for cardiac events who are already receiving an effective LDL-C lowering
7. Merck shocks with CETP cholesterol study win; Ra Pharma’s scant PNH data
News, analysis and market chatter from the corner of biotech and Wall Street.
8. Google Slapped With $2.7 Billion EU Fine Over Search Results
The European Union’s antitrust regulator fined Alphabet’s Google a record $2.71 billion for favoring its own comparison-shopping service in search results.
9. EU antitrust regulators hit Google with record 2.42 billion euro fine
EU antitrust regulators slapped a record 2.42-billion-euro ($2.7 billion) fine on Alphabet unit Google on Tuesday by illegally favoring its shopping service.
10. Why Google just got fined €2.4 billion for Google Shopping
Google has been dominant in search since 2008, EU regulators found.
11. Bio Stocks™ on Twitter
“$MRK REVEAL Outcomes Study of Anacetrapib Meets Primary Endpoint, Significantly Reducing Major Coronary Events”
Technology News
And because she works for Amazon PR and we only talked to test the device it would kind of weird for her to call me first thing in the morning on a Sunday.
And although been around forever doing one from a mobile phone or a desktop computer never felt quite as futuristic as this pulsing thing in my kitchen always watching me and always listening ready to do what I tell it.
I asked if it did the same thing with the camera and what other security precautions it had to keep unauthorized people from looking in but an Amazon spokesperson give me any further details.
It subsequently extended the practice to France in October Italy the Netherlands and Spain in May the Czech Republic in February and Austria Belgium Denmark Norway Poland and Sweden in November.
Since the beginning of each abuse Google comparison shopping service has increased its traffic in the United Kingdom in Germany in France in the Netherlands in Spain and in Italy.
In combination with the Commission other findings this shows that Google practices have stifled competition on the merits in comparison shopping markets depriving European consumers of genuine choice and innovation.
Next up on Apple agenda is augmented reality the act of superimposing digital data and visuals atop a live video feed of your surroundings something that Google Microsoft and many others have been experimenting with for a long time.
And while it looks to be functionally as flexible and capable as Google Tango check out some early examples of fanciful experiments with ARKit its broader audience makes it much more enticing for serious developers to invest their time and money into.
That how stuff goes mainstream as a big wave of change that touches everyone from casual Pokémon Go players to serious home DIY geeks figuring out how to arrange their living room furniture.
The shares pared some of those losses after Waymo unit tapped Avis to manage its fleet of autonomous vehicles in Phoenix.
After spiraling costs and headcount veteran executive Bob Mansfield was appointed to head the team which is known as Project Titan internally.
Chief Executive Officer Tim Cook acknowledged that such a system was the focus of automotive efforts in an interview with Bloomberg Television earlier this month.
TL DR unfixed Skylake and Kaby Lake processors could in some situations dangerously misbehave when is enabled.
As described in official public Intel documentation processor specification updates Errata Short Loops Which Use Registers May Cause Unpredictable System Behavior.
Based on this date range microcode revision and higher for Kaby Lake processors with signatures and fix the issue.
What started a few years ago with sequential inference and proactive interface is now using all the artificial intelligence machine learning computer vision buzzwords and the technologies behind them to bring more information and more features to us hopefully before we even know we need them.
We likely have to wait until Apple security white paper is delivered and explains the process in more detail but it sounds like from the moment you turn on High Sierra iOS all your threads will show up on all your devices current and to come.
Apple was first to market with a mainstream digital assistant but the company lack of early focus and acceleration has allowed Google Amazon Microsoft and others to catch up and in many people opinions race ahead.
Google lost its biggest regulatory battle yet getting a record billion fine from European Union enforcers who say the giant skewed results to thwart smaller shopping search services.
decision marks the end of a probe fueled by complaints from small shopping websites as well as bigger names including News Axel Springer SE and Microsoft European politicians have called on the EU to sanction Google or even break it up while critics claim regulators are targeting successful American firms.
While said American firms are under no specific fire because of their nationality transatlantic tensions are already on the rise after President Donald decision to pull out of the Paris climate accord adding to concerns over global trade.
Avis gives Waymo a potential asset that rivals like the major automakers and Uber Technologies Inc already have a sprawling network of traditional cars and customers that could be transformed into an autonomous transport service over time.
De Shon said Avis will retrofit select facilities in the Phoenix area to accommodate minivans including adding tailored tents to protect them from rain and plan to buy additional real estate.
Despite recent demonstrations of progress Waymo must pass several technical and regulatory hurdles before bringing fully driverless cars to multiple cities and climates.
McMansion Hell is a Tumblr blog that highlights the absurdity of giant real estate properties and the ridiculous staging and photography that are omnipresent in their sales listings.
It has since gone viral but now facing potential legal charges by real estate site Zillow for allegedly violating the terms of service by reproducing the images on her blog.
She also adds information about the history and characteristics of various architecture styles and uses photos from the likes of Zillow and Redfin to illustrate how so many real estate listings inaccurately use the terms.
by Alpha | Jun 16, 2017 | Pre-Market
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4. CELG:$CELG upgraded to Outperform from Market Perform at Leerink. PT $150
5. WFM:Whole Foods Market $WFM Halted, News Pending
8. CLSN:$CLSN ↑ 60% PM
Trending News Headlines
1. Amazon to Buy Whole Foods
Amazon to buy Whole Foods for $42 per share, Bloomberg News reports.Developing…
2. Voclosporin Remission Data from the Phase IIb AURA-LV Study Highlighted at EULAR 2017
Aurinia Pharmaceuticals Inc. (NASDAQ:AUPH) (TSX:AUP) (“Aurinia” or the “Company”) a clinical stage biopharmaceutical company f
3. Amazon to Buy Whole Foods for $13.7 Billion
Amazon said it would buy Whole Foods Market for $13.7 billion as the giant internet retailer makes a deeper push into the grocery space.
4. Amazon is buying Whole Foods in a deal valued at $13.7 billion
This story is developing. Please check back for further updates.
5. Detailed Quote
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6. Snap Has Shed an Astounding $13 Billion in Value and Now the Stock Is Trading Near Its IPO Price
The stock’s gains have vanished.
7. Apple Poaches Sony TV Executives to Lead Push Into Original Content
Apple has poached two top Hollywood television executives from Sony to spearhead an ambitious push into the original programming business.
8. Hyatt threatens to check out of Expedia
Hyatt Hotels is playing hardball with Expedia. Fed up with the hefty fees it pays to the online travel giant in exchange for room bookings, Hyatt is threatening to exit Expedia’s platform by July 3…
9. The Forward Curve for Oil Prices Suddenly Looks Awful for OPEC
As if a mini-collapse in oil prices wasn’t bad enough for OPEC, the pattern in which futures contracts are trading years from now has flipped into the worst possible structure for the exporter group.
10. dough on Twitter
“@tgtxdough BMO $RIGL estimate RIGL shares could see 15-30% upside on filing acceptance, expected by June 17.”
Technology News
Title II of the Communications Act is what provides the legal foundation for net neutrality and prevents Internet Service Providers like Comcast Verizon and AT T from slowing down and blocking websites or charging apps and sites extra fees to reach an audience which they then pass along to consumers.
Without net neutrality the Internet will become more like Cable TV where the content you see is what your provider puts in front of you.
Websites Internet users and online communities will come together to sound the alarm about the attack on net neutrality.
In February a former employee detailed in a public blog post a history of what she said was sexual harassment and unresponsive management setting off a investigation that unearthed embarrassing corporate misbehavior at the company.
Privately investigators and Uber employees obtained and discussed the medical records as the case progressed three people familiar with the matter but who were not authorized to speak publicly about it have said.
The complaint accuses Alexander of obtaining medical records in India and then carrying them around with him speaking about them and spreading the conspiracy theory to other members of Uber management.
true the weakening of US net neutrality laws will unlikely materially impact Netflix business or service but we would be where we are today without an open internet the spokesperson wrote.
Netflix has always been a bit opportunistic about net neutrality and it hard to draw a connection between its growing subscriber count and its dwindling support for open internet policies.
Last time around during a protest organized by the same group websites including Kickstarter Tumblr and Reddit filled their sites with spinning wheels indicating that they were taking forever to load a statement against the internet fast and slow lanes that losing net neutrality might create.
As Recode first reported following the incident Alexander obtained her medical records and carted the file around for many months after showing it to a number of executives including Michael and Kalanick.
is shocking that Travis Kalanick could publicly say that Uber would do everything to support our client and her family in her recovery when he and other executives were reviewing illegally obtained medical records and engaging in offensive and spurious conspiracy theories about the brutal rape she so tragically suffered the attorney Douglas Wigdor said in a statement.
executives duplicitously and publicly decried the rape expressing sympathy for Plaintiff and shock and regret at the violent attack while privately speculating as outlandish as it is that she had colluded with a rival company to harm business the suit reads.
Facebook is where people post pictures with their friends get their news form support groups and hold politicians to account.
What started out as a way for college students in the United States to stay in touch is now used by nearly billion people around the world.
We debate these questions fiercely and freely inside Facebook every day and with experts from around the world whom we consult for guidance.
intelligence agencies and allies consider the law vital to national security but privacy advocates have criticized Section for allowing the incidental collection of data belonging to an unknown number of Americans without a search warrant.
Government surveillance activities under the FISA Amendments Act have violated Americans constitutionally protected rights the group of about three dozen lawmakers known as the House Freedom Caucus said in a statement.
The intraparty dissent among Republicans in Congress over Section resembles a debate that took place two years ago when lawmakers disagreed sharply over whether to curtail a National Security Agency program that collected call metadata in bulk a practice exposed publicly by former intelligence contractor Edward Snowden.
In February a former employee detailed in a public blog post a history of what she said was sexual harassment and unresponsive management setting off a investigation that unearthed embarrassing corporate misbehavior at the company.
Privately investigators and Uber employees obtained and discussed the medical records as the case progressed three people familiar with the matter but who were not authorized to speak publicly about it have said.
The complaint accuses Alexander of obtaining medical records in India and then carrying them around with him speaking about them and spreading the conspiracy theory to other members of Uber management.
As Tausif Noor has written in an excellent essay on the collateral societal damage of a platform controlling whether we think our friends are safe or not by and institutionally entering into matters Facebook takes on new responsibilities for responding to them.
While the company likely had the best of intentions in developing the feature which after all grew out of organic site usage following the earthquake and tsunami in Japan the result at this point looks like an insensible that encourages people to overreact to tragic events when the sane and rational response would actually be the opposite stay calm and worry unless you hear otherwise.
If so Facebook is directly linking its behavioral nudging of users via Safety Check with a revenue generating feature that will let it take a cut of any money raised to help victims of the same tragedies.
Although academic research finds that the radicalization of members of groups like ISIS and Al Qaeda primarily occurs offline we know that the internet does play a role and we want Facebook to be used for any terrorist activity whatsoever.
Our Community Operations teams around the world which we are growing by people over the next year work hours a day and in dozens of languages to review these reports and determine the context.
also worked with Affinis Labs to host hackathons in places like Manila Dhaka and Jakarta where community leaders joined forces with tech entrepreneurs to develop innovative solutions to push back against extremism and hate online.
by Alpha | Jun 5, 2017 | Pre-Market
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3. LOXO:$LOXO upgraded to Buy from Neutral at Citi. PT $86 from $45
5. XOM:$XOM upgraded to Sector Outperform @ Scotia Howard Weil interesting as XOM breaking Sup at $80 with room to $75-77 on downside
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2. ECYT:Wedbush downgrades $ecyt from outperform to neutral & $2 PT.
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3. JUNO:$JUNO JCAR017 50% CR rate at 3 months in DLBCL. They’re back. #ASCO17
6. LOXO:$LOXO upgraded to Buy from Neutral at Citi. PT $86 from $45
7. GLYC:$GLYC presents encouraging data from Ph1/2 trial of GMI-1271 in Patients with Acute Myeloid Leukemia at ASCO
12. JNJ:Old prostate cancer CW: Xtandi > Zytiga. #ASCO17 CW: Zytiga > Xtandi $JNJ $PFE David Hung: ♂️
Trending News Headlines
1. Press Release | Blueprint Medicines
CAMBRIDGE, Mass. , June 5, 2017 /PRNewswire/ — Blueprint Medicines Corporation (NASDAQ: BPMC), a leader in discovering and developing targeted kinase medicines for patients with genomically defined diseases, today announced new Phase 1 clinical data and outlined registration plans for BLU-285, a potent and highly selective PDGFRα and KIT inhibitor in development as a potential treatment for patients with advanced gastrointestinal stromal tumors (GIST). In patients with PDGFRα-driven GIST harboring a D842 mutation, the data showed an objective response rate (ORR) of 60 percent and an estimated 9-month progression free survival (PFS) of 87 percent. Among patients with treatment-resistant KIT-driven GIST, tumor reduction was observed in eight of 14 evaluable patients treated at dose levels of at least 300 mg once daily (QD). BLU-285 was well tolerated, and most adverse events (AEs) reported by investigators were Grade 1 or 2. The data will be presented today in an oral presentation during the “GIST: Imatinib and Beyond” session from 1:15 to 2:45 p.m. CT (Abstract 11011) at the 2017 ASCO Annual Meeting in Chicago .
2. Aurinia Presents Additional Data from Phase Iib Aura-Lv Study, Demonstrating Stable Renal Function and Blood Pressure without Electrolyte Complications Through 48 Weeks
Aurinia Pharmaceuticals Inc. (NASDAQ:AUPH)(TSX:AUP) (“Aurinia” or the “Company”) a clinical stage biopharmaceutical company fo
3. Akebia Prevails in Two Additional European Patent Disputes
Akebia Therapeutics, Inc. (NASDAQ:AKBA), a biopharmaceutical company focused on delivering innovative therapies to patients with kidney disease t
4. APHINITY trial (BIG 4-11): A randomized comparison of chemotherapy (C) plus trastuzumab (T) plus placebo (Pla) versus chemotherapy plus trastuzumab (T) plus pertuzumab (P) as adjuvant therapy in patients (pts) with HER2-positive early breast cancer (EBC). | 2017 ASCO Annual Meeting Abstracts
LBA500 APHINITY trial (BIG 4-11): A randomized comparison of chemotherapy (C) plus trastuzumab (T) plus placebo (Pla) versus chemotherapy plus trastuzumab (T) plus pertuzumab (P) as adjuvant therapy in patients (pts) with HER2-positive early breast cancer (EBC). Gunter Von Minckwitz, Marion Jennifer Procter, Evandro De Azambuja, Dimitrios Zardavas, Adam Knott, Giuseppe Viale, Thomas M. Suter, Amal Arahmani, Nathalie Rouchet, Emma Clark, Mark Benyunes, Istvan Lang, Christelle Levy, Denise A. Yardley, Jose Bines, Richard D. Gelber, Martine J. Piccart-Gebhart, Jose Baselga; German Breast Group (GBG), Neu-Isenburg, Germany; Frontier Science (Scotland) Ltd., Kingussie, United Kingdom; Institut Jules Bordet, Brussels, Belgium; Breast International Group, Brussels, Belgium; Roche Products, Ltd., Welwyn, United Kingdom; Department of Pathology, European Institute of Oncology and University of Milan, Milan, Italy; University Hospital Bern, Bern, Switzerland; Genentech, Inc., San Francisco, CA; National Institute of Oncology, Budapest, Hungary; Centre François Baclesse, Caen, France; Sarah Cannon Research Institute and Tennessee Oncology, PLLC, Nashville, TN; National Cancer Institute, Rio de Janeiro, Brazil; Dana-Farber Cancer Institute, Boston, MA; Jules Bordet Institute, Brussels, Belgium; Memorial Sloan Kettering Cancer Center, New York, NY
5. Andy Biotech on Twitter
“$JUNO some mixed stock reaction looks like due to another patient death”
6. Insys Therapeutics, Inc. Releases Statement on Its Ongoing Mission
PHOENIX, June 05, 2017 (GLOBE NEWSWIRE) — Insys Therapeutics, Inc. (NASDAQ: INSY ) (“Insys” or “the Company”) issued a response to the recent media reports that highlight concerns with the Company’s past commercial practices and former employees. Insys reiterates its commitment to:
7. Clinical Trial Data for Combination of Epacadostat and Opdivo® (nivolumab) Demonstrate Durable Clinical Responses in Patients with Melanoma and Head and Neck Cancer
Clinical Trial Data for Combination of Epacadostat and Opdivo (nivolumab) Demonstrate Durable Clinical Responses in Patients with Melanoma and Head an
8. What to expect from WWDC 2017
It’s that time of year again. Thousands of developers are set to descend upon the South Bay to get their software on. And the rest of the Apple watching world..
9. Press Release | Investor Relations | Bluebird Bio
– 100% of the 15 evaluable patients in active dose cohorts (doses above 50 x 10 6 ) achieved an objective response; overall response rate (ORR) across all cohorts (n=18) is 89% –
10. Oil prices dip on fears Middle East spat could harm OPEC cuts
Oil prices reversed gains to trade down on Monday on concerns that the cutting of ties with Qatar by top crude exporter Saudi Arabia and other Arab states could hamper a global deal to reduce oil production.
11. bluebird bio and Celgene Corporation Announce Updated Clinical Results from Ongoing First-in-Human Multicenter Study of bb2121 Anti-BCMA CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma at ASCO Annual Meeting
bluebird bio, Inc. (NASDAQ:BLUE), and Celgene Corporation (NASDAQ:CELG) today announced that updated results from the ongoing CRB-401 Phase 1 clinical
12. Bristol-Myers Squibb’s Opdivo, Yervoy put the brakes on mesothelioma in phase 2 | FiercePharma
New data suggest immunotherapy could stall mesothelioma progression—and that when it comes to Bristol-Myers Squibb’s checkpoint inhibitors, two might be better than one.
13. European Patent Office Maintains FibroGen Patent Relating to Hypoxia-Inducible Factor (HIF) Prolyl Hydroxylase Inhibitor Technology
SAN FRANCISCO, June 05, 2017 (GLOBE NEWSWIRE) — FibroGen, Inc. (NASDAQ: FGEN ), a science-based biopharmaceutical company, announced today that a FibroGen European patent relating to the therapeutic use of certain small molecule inhibitors of hypoxia-inducible factor (HIF) prolyl hydroxylase was maintained by the European Patent Office.
Technology News
Where free collaborative software projects were once the flags flown by indie developers bucking corporate computing today even companies like Exxon Mobil and Wells Fargo are releasing their own open source tools.
Beyond the consequences for open source projects themselves the diversity problem could actually make the larger tech entrenched imbalances worse.
One thing many respondents said drives them away from open source projects are negative interactions such as rudeness stereotyping the more extreme end of the and outright harassment.
Where free collaborative software projects were once the flags flown by indie developers bucking corporate computing today even companies like Exxon Mobil and Wells Fargo are releasing their own open source tools.
Beyond the consequences for open source projects themselves the diversity problem could actually make the larger tech entrenched imbalances worse.
One thing many respondents said drives them away from open source projects are negative interactions such as rudeness stereotyping the more extreme end of the and outright harassment.
The number of layers is carefully constrained so the mobile graphics processor can achieve the fast frame rates needed for smooth animation and user interaction with very low power usage.
The challenge was that replacing the file system with a completely new implementation that provides major new functionality while at the same time appearing essentially unchanged to the vast array of existing software is an incredibly daunting task.
Especially because key Windows core engineering was busy with other efforts security and WinFS was built as a component that would sit on the side and provide additional functionality for searching and rich queries.
The number of layers is carefully constrained so the mobile graphics processor can achieve the fast frame rates needed for smooth animation and user interaction with very low power usage.
The challenge was that replacing the file system with a completely new implementation that provides major new functionality while at the same time appearing essentially unchanged to the vast array of existing software is an incredibly daunting task.
Especially because key Windows core engineering was busy with other efforts security and WinFS was built as a component that would sit on the side and provide additional functionality for searching and rich queries.
In May they posed for photos at a cosplay conference in Japan dressed as a character from the game Metal Gear Solid complete with identical bikini tops ripped black tights and ammunition belts.
While Luckey became a tech icon for reviving interest in virtual reality his politics burst into view in September when The Daily Beast published an article saying he had quietly funded a nonprofit Nimble America.
Those familiar with the plan say Luckey believes his system which can be mounted on telephone poles can be built far more cost effectively than proposed wall on the Mexican border and with fewer obstacles from landowners.
ET Interest in bitcoin has been skyrocketing again as the price of the digital currency has hit new highs.
That only helps bitcoin startups in the eyes of investors.
One of these startups Coinbase is in talks with potential investors on a new round of funding at a valuation of more than billion according to people familiar with the matter.
When early efforts to turn around business and spin off the Alibaba shares failed to bear fruit another hedge fund manager Jeffrey Smith of Starboard Value led a campaign to push for her ouster.
Mayer has come under more scrutiny than most Silicon Valley chief executives in part because of the Superwoman image she cultivated in an industry dominated by men the computer scientist and tireless manager who still wrote code for fun while raising three young children and looking stylish in Oscar de la Renta.
The DNA and technology were built around its original identity as a web portal a powerful position in the early but increasingly outmoded in the mobile era as apps and phone platforms like iOS and Android became the gateways to the internet.
In May they posed for photos at a cosplay conference in Japan dressed as a character from the game Metal Gear Solid complete with identical bikini tops ripped black tights and ammunition belts.
While Luckey became a tech icon for reviving interest in virtual reality his politics burst into view in September when The Daily Beast published an article saying he had quietly funded a nonprofit Nimble America.
Those familiar with the plan say Luckey believes his system which can be mounted on telephone poles can be built far more cost effectively than proposed wall on the Mexican border and with fewer obstacles from landowners.
One of challenges is to balance attracting outside investors with its interest in supporting existing teams that have helped grow League of Legends to where it is today.
too risky said Jace Hall the chief executive officer of Echo Fox which currently competes in League Championship Series LCS.
And in league the rich get richer Teams that perform better will receive a larger share of revenue which will come largely from the million streaming deal it signed with BAMTech last year.
When early efforts to turn around business and spin off the Alibaba shares failed to bear fruit another hedge fund manager Jeffrey Smith of Starboard Value led a campaign to push for her ouster.
Mayer has come under more scrutiny than most Silicon Valley chief executives in part because of the Superwoman image she cultivated in an industry dominated by men the computer scientist and tireless manager who still wrote code for fun while raising three young children and looking stylish in Oscar de la Renta.
The DNA and technology were built around its original identity as a web portal a powerful position in the early but increasingly outmoded in the mobile era as apps and phone platforms like iOS and Android became the gateways to the internet.
