by Alpha | Sep 20, 2017 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
2. MS, PFE:$PFE upgraded to Overweight from Equal-Weight @ $MS
3. PFE:$PFE upgraded to Overweight From Equal-Weight at Morgan Stanley
DOWNGRADES
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4. MU:$MU an upgrade a day keeps the downside away. another analyst upgrade this morning
10. PFE:$PFE upgraded to Overweight From Equal-Weight at Morgan Stanley
11. WDC:$WDC down 5% as bain the Toshiba buyer
13. FMC:Lithium stocks have been ripping in 2017. Here’s $FMC, which is up 62% this year and at all-time highs ->…
Trending News Headlines
1. Apple Watch Series 3 Review: Untethered… and Unreliable
Apple Inc. unshackles the Apple Watch Series 3 from your iPhone by giving it its own cellular connection—but the device still isn’t a fully stand-alone wrist computer.
2. Karyopharm Announces Successful Outcome from Phase 2 Portion of Phase 2/3 SEAL Study Evaluating Selinexor in Patients with Previously Treated Advanced Dedifferentiated Liposarcoma
– The Primary Objective of Progression-Free Survival Favored Selinexor over Placebo; Hazard Ratio of 0.60 (RECIST v1.1), Representing a 40% Reduction in Risk of Progression or Death –
3. Matthew Herper on Twitter
“Leerink on $ALNY”
4. Alnylam hits all key endpoints in crucial trial of rare disease drug
The age of RNA interference drugs has arrived. Alnylam Pharmaceuticals announced positive results Wednesday from a closely watched phase 3 clinical trial of patisiran, the company’s lead drug designed to treat a rare nerve disorder known as familial amyloid polyneuropathy (FAP.) Most importantly, the safety profile of patisiran in the FAP study looks clean, assuaging …
5. Alnylam and Sanofi Report Positive Topline Results from APOLLO Phase 3 Study of Patisiran in Hereditary ATTR (hATTR) Amyloidosis Patients with Polyneuropathy
Alnylam Pharmaceuticals, Inc. (Nasdaq:ALNY), the leading RNAi therapeutics company, and Sanofi Genzyme, the specialty care global business unit o
6. Matthew Herper on Twitter
“How long does drug development take? Here is my profile of $alny from 2003.
7. Alnylam Pharmaceuticals, Inc. – Alnylam and Sanofi Report Positive Topline Results from APOLLO Phase 3 Study of Patisiran in Hereditary ATTR (hATTR) Amyloidosis Patients with Polyneuropathy
8. Matthew Herper on Twitter
“Maybe the most impressive part of the $ALNY $SNY release.”
9. Alnylam and Sanofi Report Positive Topline Results from APOLLO Phase 3 Study of Patisiran in Hereditary ATTR (hATTR) Amyloidosis Patients with Polyneuropathy
Alnylam Pharmaceuticals, Inc. , the leading RNAi therapeutics company, and Sanofi Genzyme, the specialty care global business unit of Sanofi, announced today that the APOLLO Phase 3 study of patisiran, an investigational RNAi therapeutic being developed for patients with hereditary ATTR amyloidosis
10. Alnylam achieves breakthrough RNAi success as PhIII patisiran study hits all goals
lede lede para para Alnylam investors $ALNY can now start breathing again. The big Cambridge, MA-based biotech says that their Phase III study of patisiran — partnered with Sanofi — scored a positive hit for the primary as well as all secondary hits in treating rare cases of hereditary ATTR
11. Brad Loncar on Twitter
“Awesome quote by @JMaraganore. Congrats to him and $ALNY. Biotech for the win.”
Technology News
This story can only be viewed in the App Store on iOS with your iPhone or iPad.
was running a wild west of online advertising fraud allowing Uber ads on websites we wanted nothing to do with and fraudulently claiming credit for app downloads that happened without a customer ever clicking on an.
are shocked by allegations which are unsubstantiated completely without merit and purposefully inflammatory so as to draw attention away from unprofessional behaviour and failure to pay suppliers.
One nontransparent practice disclosed in the report involved agencies getting rewarded with rebates from media companies for reaching spending thresholds on behalf of their clients without knowledge.
ET A group representing investors is leading a lawsuit against the Trump administration claiming it took illegal steps to prevent an immigration policy that would have helped founders stay in the to build startups.
In a legal complaint filed Tuesday the National Venture Capital Association along with other plaintiffs claims the Department of Homeland Security violated rules around administrative procedures when it delayed the start of the International Entrepreneur Rule one week.
The phone will also arrive in Black and be available with or storage.
The Pixel XL will cost over months and the version will jump to.
Last Post Here is the New Google Daydream View It Cost Next Post Here is the Pixel in Kinda Blue White and Black Starting at.
ET CUPERTINO your iPhone or in your hand.
Close your eyes and imagine it with a shinier glass back a speedier processor improved cameras and wireless charging.
That may sound like a perfectly good upgrade and on Tuesday it was the best iPhone Apple ever a few minutes later when the company showed off the iPhone X which has all of that and more.
However Hitachi Vantara execs say it will not complete directly with Microsoft Azure Amazon Web Services or Google Cloud Platform to sell basic computing storage and networking to customers.
Together the three component companies claim customers including Disney dis BMW bmwyy Verizon vz InfoSys and Marks Spencer.
One priority will be to push Insight Lumada Internet of things technology as a platform for connected devices in industrial settings.
new Series smartwatch starts shipping this Friday and the biggest feature change between last model and this new Watch is that it has cellular capabilities.
While writing my review of the Apple Watch Series with LTE capabilities I experienced notable connectivity issues.
Unfortunately we still know when that software release is expected or exactly how it will fix the issue of the Watch connecting to cellular networks when supposed to.
Uber Technologies facing a federal probe into whether it broke laws against overseas bribery has embarked on a review of its Asia operations and notified officials about payments made by staff in Indonesia people with knowledge of the matter said.
As the Justice Department looks into a possible criminal case Uber is working with law firm Myers LLP to examine records of foreign payments and interview employees raising questions about why some potentially problematic business dealings disclosed sooner said the people who asked not to be identified because the details are private.
The head of compliance left this month and Salle Yoo the chief legal officer also said she plans to depart after helping new CEO Dara Khosrowshahi find her successor.
When Google takes the stage on October at a event in San Francisco most of us expect there to be related product announcements too.
heard rumors about a Google Home possibly being on the way and today we can confirm that it exists how much it costs and the colors be available in.
According to the information viewed the Google Home Mini official name will arrive in Chalk Charcoal and Coral colors.
ET A group representing investors is leading a lawsuit against the Trump administration claiming it took illegal steps to prevent an immigration policy that would have helped founders stay in the to build startups.
In a legal complaint filed Tuesday the National Venture Capital Association along with other plaintiffs claims the Department of Homeland Security violated rules around administrative procedures when it delayed the start of the International Entrepreneur Rule one week.
by Alpha | Sep 19, 2017 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
DOWNGRADES
4. SUPN:$SUPN downgraded to Hold from Buy at Stifel.
EARNINGS
Trending Social Alerts
1. TSLA:Jefferies analysts downgrading $TSLA to $280. Totally BS. It does NOT matter what they think. THIS is what MATTERS.
10. NVAX:$NVAX Data From Phase 1/2 Trial of NanoFlu Vaccine Expected by the EOY’17
12. CVS:$CVS Upgrade RBC Capital Initiates Coverage On CVS Health with Outperform Rating, Announces $95.00 Price Target
Trending News Headlines
1. Acceleron to Develop Sotatercept in Pulmonary Arterial Hypertension
Acceleron Pharma Inc. (NASDAQ:XLRN), a leading biopharmaceutical company in the discovery and development of TGF-beta therapeutics to treat serious an
2. Brooklyn Seen as Best Bet for NYC to Win New Amazon Headquarters
Brooklyn may emerge as an attractive lure in New York City’s long-shot bid to become Amazon.com Inc.’s new home.
3. With new operating system, Apple revamps its money-making App Store
Apple Inc’s newest operating system for iPhones and iPads introduces changes to its marketplace for third-party software to satisfy app developers and add new so-called augmented reality apps.
4. Joe Kunkle on Twitter
“$AMGN on acquisitions, cash deployment and tax reform”
Technology News
Yesterday Net Neutrality day of action showed that the Internet users care about an open playing field and do want a handful of companies to decide what we can and ca do online.
Dear Tim Jeff and colleagues On behalf of the Electronic Frontier Foundation I would like to formally submit our request for an appeal of the Director decision to publish Encrypted Media Extensions as a Recommendation announced on July.
Dubbed Encrypted Media Extensions EME this mechanism was crafted by engineers from Google Microsoft and Netflix and has been in development for some time.
Second and quite strange if you look carefully into Siri Search Suggestions font see that jagged especially Latin script near edges not smooth at all even compare to input text on same screen.
However during actual usage due to the for some digits very obvious for user that text is closer to left edge which show any pro compared to iOS.
This faux font issue from Safari has appeared in iOS Beta and submitted bug report through Feedback app earlier in August the case number is.
EME is already widely adopted as a direct result of broad collaboration in among major organizations such as Google Microsoft Netflix Mozilla Apple CableLabs Adobe and has significant implementation across Web browsers.
Michael Wise CTO Universal Pictures Integration of DRM into web browsers delivers improved performance battery life reliability security and privacy to users watching their favorite TV shows and movies on Netflix and other video services.
Mark Richer President Advanced Television Systems Committee IPTV Forum Japan IPTVFJ sincerely congratulates that World Wide Web Consortium has published Encrypted Media Extensions EME as a Recommendation.
Before Google Assistant was a thing the Mountain View company spoke of the concept as without turning the contextual awareness of your phone into a series of automatic triggers to surface useful information.
Most of us are familiar with these still rudimentary assistive qualities which synergize nicely with voice controls and searches to set the stage for a future where we just talk to our smart and informed pocket computers.
When you buy one of these phones you should expect small plumes of perfume to waft up at your nostrils a tiny trumpet band to start playing and a handwritten note of thanks from Samsung Mobile chief JK Shin.
Roku may not have the same buzz as Google Facebook or even Snap but when it goes public it plans to take a page from the books of those companies creating an ownership structure that will give its CEO and other insiders outsized power.
The voting power that will be held by Wood and the other insiders after the offering will limit your ability to influence corporate matters Roku warned prospective shareholders in a updated regulatory document filed with the Securities and Exchange Commission Monday.
The company also licenses its software for use in smart TVs and traditional pay TV industry boxes and it sells advertising inside of its interface and some of the videos it streams.
Second and quite strange if you look carefully into Siri Search Suggestions font see that jagged especially Latin script near edges not smooth at all even compare to input text on same screen.
However during actual usage due to the for some digits very obvious for user that text is closer to left edge which show any pro compared to iOS.
This faux font issue from Safari has appeared in iOS Beta and submitted bug report through Feedback app earlier in August the case number is.
Second and quite strange if you look carefully into Siri Search Suggestions font see that jagged especially Latin script near edges not smooth at all even compare to input text on same screen.
However during actual usage due to the for some digits very obvious for user that text is closer to left edge which show any pro compared to iOS.
This faux font issue from Safari has appeared in iOS Beta and submitted bug report through Feedback app earlier in August the case number is.
The Keybase app takes care of all the crazy stuff such as rotating keys when Alice later boots Carter because he a lousy.
From passing around technical secrets to discussing more tender business dealings these groups will want data that ca be decrypted by others inside their own company.
Nothing we offering for free now will flip to a pay model so if you make a person team now and start using it you wo someday be faced with a credit card screen just to get your files or messages.
10.
EME is already widely adopted as a direct result of broad collaboration in among major organizations such as Google Microsoft Netflix Mozilla Apple CableLabs Adobe and has significant implementation across Web browsers.
Michael Wise CTO Universal Pictures Integration of DRM into web browsers delivers improved performance battery life reliability security and privacy to users watching their favorite TV shows and movies on Netflix and other video services.
Mark Richer President Advanced Television Systems Committee IPTV Forum Japan IPTVFJ sincerely congratulates that World Wide Web Consortium has published Encrypted Media Extensions EME as a Recommendation
by Alpha | Sep 18, 2017 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
DOWNGRADES
EARNINGS
Trending Social Alerts
4. ITRI:$ITRI Itron to Acquire Silver Spring Networks to Accelerate Smart Grid and Smart City Innovation and Growth From our Stock News Alerts App
8. USDCAD:TODAY’s Daily #TradingSignals Video from @tradingsafely1 $USDCAD HOT TODAY >> #Forex #Traders WATCH HERE >>>…
9. UTX:$UTX Northrop Grumman to buy missile maker Orbital for $7.8 billion, create new business sector Now on
10. EFX:Spoke to a friend who is a top cyber security expert at a major bank this weekend. Said $EFX breach was pure stupidity or negligence
13. JAGX:$JAGX offering
14. SILVER:note @federalreserve is now dumping BILLIONS in naked paper $gold $silver to bring metals down for wednesday……as usual
15. RARE:$RARE to buy $DMTX for $5.50/share cash
Trending News Headlines
1. Walgreens Said to Tweak Rite Aid Deal to Clinch U.S. Approval
Walgreens Boots Alliance Inc. is poised to revise its agreement to buy individual Rite Aid Corp. stores, a move that may be enough to resolve outstanding antitrust concerns and clinch U.S. approval for a deal the companies have been pursuing in different forms for two years, said people familiar with the matter.
2. Ultragenyx Proposes to Acquire Dimension Therapeutics for $5.50 Per Share in Cash (NASDAQ:RARE)
Proposed Combination of Complementary Rare Disease Franchises Maximizes the Ability to Bring Needed New Therapies to Market Proposal Delivers Superior Value To Dimension’s Shareholders Relati…
3. Whole Foods Shows What Economists Don’t Know
Was Amazon’s price cut a good idea? Econ 101 won’t tell you.
4. Christian Fromhertz on Twitter
“$NVDA Nvidia PT Raised to $210 at BofAML on Data Center, Volta”
5. Nabriva novel antibiotic meets goals in late-stage bacterial pneumonia study
Nabriva Therapeutics (NBRV) took a big risk pushing its novel antibiotic, lefamulin, into a late-stage clinical trial in patients with hospital-acquired pneumonia without any prior clinical data. On Monday, the bet paid off. The Ireland-based company said lefamulin achieved the primary and secondary endpoints in a phase 3 study of 551 patients with community-acquired bacterial pneumonia. …
6. Patients Switched to Alkermes’ ARISTADA® Showed Significant Improvement in Schizophrenia Symptoms After Inadequate Response or Intolerance to INVEGA SUSTENNA®
Alkermes plc (NASDAQ: ALKS) today announced positive topline results from a phase 4 clinical study of ARISTADA® (aripiprazole lauroxil) extended-r
7. Nokia says to get sales boost after patent ruling
Nokia (NOKIA.HE) will start to book additional revenue from the current quarter after a ruling by an arbitration court on payments from South Korea’s LG Electronics (066570.KS) for using its smartphone patents.
Technology News
Facebook did not give copies of the ads to members of the Senate and House intelligence committees when it met with them last week on the grounds that doing so would violate their privacy policy sources with knowledge of the briefings said.
Mark Warner the top Democrat on the Senate Intelligence Committee told CNN last week that Facebook had not turned over the ads to Congress.
Warner has also called Facebook review the tip of the iceberg and suggested that more work needs to be done in order to ascertain the full scope of Russia use of social media.
government has said Facebook agreed to help create a new communications channel with the Na Son Press Populous developing countries like Vietnam are where the company is looking to add its next billion customers and to bolster its ad business.
But in recent years events as varied as the Arab Spring elections in France and confusion in Indonesia over the religion of the president have awakened governments to how they have lost some control over online speech commerce and politics on their home turf.
Africa where many people are only just beginning to get online is a greenfield for internet companies like Adriane Ohanesian for The New York Times Correction September An earlier version of this article misspelled the surname of head of public policy in Europe.
This post was authored by Edmund Brumaghin Ross Gibb Warren Mercer Matthew Molyett and Craig Williams Update CCleaner Cloud version is also reported to be affected.
On September while conducting customer beta testing of our new exploit detection technology Cisco Talos identified a specific executable which was triggering our advanced malware protection systems.
The requests also leverage HTTPS but ignore all security errors as the server currently returns a SSL certificate that was issued to the subdomain defined in the Host header field.
Intelligent Tracking Prevention collects statistics on resource loads as well as user interactions such as taps clicks and text entries.
A machine learning model is used to classify which top domains have the ability to track the user based on the collected statistics.
Check to make sure that you relying on cookies and other storage to persist if the user does not interact directly with your website on a regular basis.
There are worries about pornography about whether social networks will lead sons and daughters to date friends and about connecting to a world of seemingly limitless possibilities.
The internet also threatens another Amish bonding agent For a society in which formal education ends after eighth grade youngsters learn a trade or craft alongside a relative or other member of the community.
There are probably successful Amish businesses in the Lancaster area many of them enterprises said Donald Kraybill a retired professor at Young Center for Anabaptist and Pietist Studies.
Up to million people use the feature each and every day to post video and photo updates that disappear in hours according to Head of Messenger David Marcus.
And while Messenger remains in the early stages of making it a major hub for customer service clear Marcus has huge ambitions there.
Charlene Li principal analyst and founder of the San Altimeter Group suggests the virtual assistant remains a huge trove of untapped potential.
ET Facebook has handed over to special counsel Robert Mueller detailed records about the Russian ad purchases on its platform that go beyond what the company shared with Congress last week according to people familiar with the matter.
The information Facebook shared with Mueller included copies of the ads and details about the accounts that bought them and the targeting criteria they used the people familiar with the matter said.
Facebook policy dictates it would only turn over stored contents of any.
More than half of the new funding came from SoftBank Chief Executive Officer Stewart Butterfield said in an interview in London Monday.
But Butterfield said the additional capital will also help give large clients as well as existing and future employees confidence that Slack is here to stay.
Vision Fund raised almost billion this year and is blanketing the venture capital market and tech sector with the money.
government has said Facebook agreed to help create a new communications channel with the Na Son Press Populous developing countries like Vietnam are where the company is looking to add its next billion customers and to bolster its ad business.
But in recent years events as varied as the Arab Spring elections in France and confusion in Indonesia over the religion of the president have awakened governments to how they have lost some control over online speech commerce and politics on their home turf.
Africa where many people are only just beginning to get online is a greenfield for internet companies like Adriane Ohanesian for The New York Times Correction September An earlier version of this article misspelled the surname of head of public policy in Europe.
effort to influence voters through Facebook and other social media is a focus of special counsel Robert investigation into the election and possible links to President Donald associates according to officials familiar with the matter.
team of prosecutors and FBI agents is zeroing in on how Russia spread fake and damaging information through social media and are seeking additional evidence from companies like Facebook and Twitter about what happened on their networks said one of the officials who asked not to be identified discussing the ongoing investigation.
Alphabet Google unit said in a statement always monitoring for abuse or violations of our policies and seen no evidence this type of ad campaign was run on our A person familiar with the matter said the company been called to testify on the topic.
by Alpha | Sep 15, 2017 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
4. FSLR:$FSLR upgraded Hold to Buy at DB today price target moving to $65 from $50. Analyst citing margin improvement. Average pt on the ST 53.69
DOWNGRADES
Trending Social Alerts
1. BTCUSD:$btcusd A doji or any of the reversal candles tomorrow would be quite interesting. Says BBands, who likes candlesti…
4. NVDA:$NVDA Evercore ISI out with a big note this morning..”NVIDIA is Building the Industry Standard for AI – Raising Price Target to $250″
5. GOLD:looks like janet @federalreserve & her boyz had a very long expensive night beating down $gold $silver….NK probably didn’t help…LOL
6. ES_F:Watch your Pivots. Over night lows need to be tested $2487 $ES_F
11. AAL:American Airlines downgraded to Neutral from Overweight at JP Morgan $AAL
12. MRTX:$MRTX nice PM
Trending News Headlines
1. Donald J. Trump on Twitter
“ESPN is paying a really big price for its politics (and bad programming). People are dumping it in RECORD numbers. Apologize for untruth!”
Technology News
SAN FRANCISCO Three women who worked at Google are suing the company over its salary practices accusing the search giant of discriminating against its female employees by systematically paying them less than men who do similar jobs.
Google has been an tech innovator its treatment of female employees has not entered the century said Kelly Dermody of the law firm Lieff Cabraser Heimann Bernstein one of the lawyers for the plaintiffs in the suit.
Google is attracting particular scrutiny over how it treats female employees after a memo written by a former male software engineer for the company argued that its efforts to bring more women into technical roles were unfair and not good for business.
ET SoftBank Group is nearing an ambitious deal to take a substantial stake in Uber Technologies only if the Japanese technology investor can persuade shareholders to sell enough stock at a steep discount.
After weeks of deliberation board in recent days has been hashing out its response to a potential investment led by.
To test if these ad categories were real we paid to target those groups with three in which a ProPublica article or post was displayed in their news feeds.
are times where content is surfaced on our platform that violates our standards said Rob Leathern product management director at Facebook.
In the wake of the violent protests in Charlottesville by groups that included Nazis Facebook and other tech companies vowed to strengthen their monitoring of hate speech.
Illustrators comedians game makers and musicians use Patreon to let fans pay a monthly subscription fee for special access to their work.
The cash should give Patreon the muscle needed to compete with other big platforms that help creators monetize including YouTube and new Watch tab of original video.
Musician and videographer Jack Conte had struggled to earn enough from his work and found project crowdfunding platforms like Kickstarter provide the steady capital artists need to focus on creativity.
Alphabet has held conversations with Lyft about a potential investment in recent weeks signalling strong support for Uber Technologies main competitor according to people familiar with the matter.
While Lyft has recently focused on controlling spending the cash would allow the San startup to pursue more aggressive growth with subsidies for drivers discounts for riders and marketing.
looking to complete a fundraising deal of his own Uber is advancing on an investment from SoftBank Group and others of as much as billion most of which would allow existing shareholders to cash out.
Google was accused in a lawsuit of systematically paying male employees more than their female counterparts adding the internet giant to a growing list of technology companies sued for gender discrimination.
the same year Ellen Pao put Silicon culture front and center during a trial pitting her against the venture capital firm Kleiner Perkins Caufield Byers.
Women continue to get paid less than men despite companies and society overall making great strides in equality according to David Gottlieb a civil rights attorney at Wigdor LLP in New York who involved in the Google suit.
SAN FRANCISCO Three women who worked at Google are suing the company over its salary practices accusing the search giant of discriminating against its female employees by systematically paying them less than men who do similar jobs.
Google has been an tech innovator its treatment of female employees has not entered the century said Kelly Dermody of the law firm Lieff Cabraser Heimann Bernstein one of the lawyers for the plaintiffs in the suit.
Google is attracting particular scrutiny over how it treats female employees after a memo written by a former male software engineer for the company argued that its efforts to bring more women into technical roles were unfair and not good for business.
Facebook equips businesses with powerful ways to reach the right people with the right message.
ProPublica surfaced that these offensive education and employer fields were showing up in our ads interface as targetable audiences for campaigns.
Advertisers can report any inappropriate targeting fields directly in the ads interface or via our Help Center.
Read comments from top tech and industry leaders.
The biggest advertising organizations say Apple will the current economic model of the internet with plans to integrate technology into the new version of Safari.
The infrastructure of the modern Internet depends on consistent and generally applicable standards for cookies so digital companies can innovate to build content services and advertising that are personalized for users and remember their visits.
Safari move breaks those standards and replaces them with an amorphous set of shifting rules that will hurt the user experience and sabotage the economic model for the Internet.
by Alpha | Sep 14, 2017 | Pre-Market
PRE-MARKET MOVERS
UPGRADES
1. RARE:$RARE upgraded from Neutral to Outperform at Wedbush. PT $62
DOWNGRADES
Trending Social Alerts
1. GBPUSD:BoE: Some Withdrawal Of Stimulus Likely Appropriate In ‘Coming Months’ $GBPUSD $GBPUSD
2. LTCUSD:Okcoin $LTCUSD Weekly futures has liquidated a short position of 2300 contract at 46.853 – 2017-09-14 20:18:07
3. BTCUSD:UPDATE: $BTC $BTCUSD all going as planned. Close to a key point. RSI & Volume looking healthy. MACD could be better…
4. BLDP:What a great day – so many plays. $BLDP Ascending triangle formation + multi year breakout = great r/r. In 4.47 out…
13. USO:Dont forget that Shanghai International Energy Exchange launched 6 m ago the RMB denominated crude oil future $USO
Trending News Headlines
1. Bristol-Myers Squibb and Halozyme Enter Global Collaboration and License Agreement for ENHANZE Technology
Bristol-Myers Squibb is Committed to Enhancing Patient Care Through Delivery of Cancer Treatments by Subcutaneous Injection Halozyme to Receive $105 Million Upfront Payment, Plus Future Milestones and Royalties Provides Bristol-Myers Squibb Access to ENHANZE technology for up to 11 Targets Bristol-Myers Squibb Company (NYSE:BMY) and Halozyme Therapeutics, Inc. (NASDAQ:HALO) today announced a global collaboration and license agreement to develop subcutaneously administered Bristol-Myers Squibb immuno-oncology medicines using Halozyme’s ENHANZE® drug-delivery technology. “We are excited to partner with Halozyme to pursue potential new approaches to how our medicines are delivered to patients,” said Murdo Gordon , chief commercial officer, Bristol-Myers Squibb . “Through our work with Halozyme, we hope to improve the patient treatment experience by developing flexible and convenient treatment delivery options.” The Halozyme ENHANZE technology is based on a proprietary recombinant human
2. Up Next for the United Tech-Rockwell Tie-Up: The Antitrust Ordeal
Questions are emerging over how antitrust authorities will treat the deal between United Technologies and Rockwell Collins, amid a debate over whether the tie-up will drive up costs in the aerospace industry.
3. Jefferies sees 50% upside for shares of Michael Kors
0.82 (1.99%)
4. Looking for an I/O edge, Bristol-Myers fronts $105M to partner with Halozyme as Roche expands pact
After racking up H1 sales of $2.3 billion for its PD-1 star Opdivo, Bristol-Myers Squibb is now fronting $105 million — with a trove of $1.8 billion-plus in milestones — to see whether its hugely important immuno-oncology franchise can be helped by the delivery tech developed at Halozyme. That’s not
5. Equifax Falls After Identifying Flaw Hackers Exploited in Breach
Equifax Inc. dropped in early trading after specifying which software vulnerability hackers exploited to steal data on 143 million U.S. consumers, pointing to a flaw that computer security experts had flagged publicly early this year.
6. Alexion Could Target Sage, Ra Pharma: Analyst
BMO Capital Markets analyst M. Ian Somaiya says Alexion could view Sage Therapeutics and Ra Pharmaceuticals as potential acquisition targets. Somaiya pointed to Sage’s diverse pipeline and Ra’s diversified complement pipeline.
7. John Carroll on Twitter
“Plus another $190M deal from Roche for $HALO.
8. Thank You for Calling Equifax. Your Business Is Not Important to Us
Credit monitoring in the U.S. is a nightmare. It only took a massive public data breach to make that clear.
Technology News
Oracle announced today that they along with IBM and Red Hat will be moving Java EE to the Eclipse Foundation.
The Eclipse Foundation is focused on enabling open collaboration among individuals small companies enterprises and the largest vendors.
We look forward to supporting the Java EE community as it creates the platform for the next twenty years of business applications.
The multifaceted Russian information operation targeting the presidential election had many elements including the hacking and leaking of Democratic emails regular attacks on Hillary Clinton by the RT television channel and the online news site Sputnik and the creation of fake accounts on Facebook and Twitter.
Senator Mark Warner of Virginia the top Democrat on the Intelligence Committee told reporters on Tuesday that he wanted Facebook and Twitter to testify in public session about the Russian use of their sites.
Though some ads mentioned the presidential candidates or the election most to focus on amplifying divisive social and political messages across the ideological spectrum touching on topics from LGBT matters to race issues to immigration to gun rights wrote Alex Stamos the chief security officer.
We learned of a potential vulnerability in an internal portal in Argentina which was not in any way connected to the event that occurred in the United States last week an Equifax spokeswoman told the BBC.
The discovery came less than a week after Equifax revealed that a separate breach meant about million US consumers and an undisclosed number of British and Canadian residents might have had personal details exposed.
It simply should happen and responding that they have now fixed the issue is not the point it puts a huge question mark over whether Equifax have been applying the appropriate resources to online security elsewhere.
President Donald Trump blocked a investor from buying Lattice Semiconductor casting a cloud over Chinese deals seeking security clearance and spurring a call for fairness from Beijing.
The government is also examining an agreement by Chinese conglomerate HNA Group to buy a stake in SkyBridge Capital LLC the firm founded by Anthony Scaramucci who was briefly White House communications director.
China the largest chip market has been on the hunt for acquisitions in the field as it looks to build a domestic supply and rely less on imports as the billion global semiconductor industry undergoes its biggest wave of consolidation.
The decision represents a sharp response to what intelligence agencies have described as a national security threat posed by Russia in cyberspace following an election year marred by allegations that Moscow weaponized the internet in an attempt to influence its outcome.
Rob Joyce the White House cyber security coordinator said Wednesday at the Billington CyberSecurity Summit that the Trump administration made a to order Kaspersky products removed from federal agencies.
Also on Wednesday Democratic Senator Amy Klobuchar wrote to DHS asking whether the agency used Kaspersky products in relation to any critical infrastructure such as election equipment banks or energy suppliers and if it knew whether any voting systems used the software.
In a world where we get our groceries delivered in just two hours through Instacart or Amazon Fresh the humble corner bodega as they are known in New York and Los performs a valuable function.
In fact replacing that beloved institution seems explicit in the very name of venture a Spanish term synonymous with the tiny stores that dot urban landscapes and are commonly run by people originally from Latin America or Asia.
Bodega has very accurate demographic details about the people who live in a particular community and would use the service giving brands a chance to put particular products in front of their target consumer.
team of nearly employees includes two native Argentinians who spent some time examining South American operations online after the company disclosed the breach involving its business units in North America.
It took almost no time for them to discover that an online portal designed to let Equifax employees in Argentina manage credit report disputes from consumers in that country was wide open protected by perhaps the most password combination ever.
It is unclear whether the complete lack of security at Veraz unit in Argentina was indicative of a larger problem for the online employee portals across the region but difficult to imagine they could be any worse.
And run by people who in addition to selling everything from toilet paper to milk also offer an integral human connection to their patrons that our automated storefronts never will.
We see a future where anyone can own and operate a Bodega delivering relevant items and a great retail experience to places no corner store would ever open.
Like bodegas we want to build a shopping experience that stands for convenience and ubiquity for people who have easy access to a corner store.
The document seen by Reuters will be published on Thursday the day before EU finance ministers begin a meeting in the Estonian capital Tallinn in which they will discuss how to increase taxes on large online businesses accused of paying too little in Europe.
This resulted in estimated revenue losses for EU states other than Ireland of between and billion euros between and the report concluded.
He plans to introduce an amendment that would force online multinationals to pay taxes in the EU countries where they are present with a that generates at least million euros of annual turnover.
President Donald Trump blocked a investor from buying Lattice Semiconductor casting a cloud over Chinese deals seeking security clearance and spurring a call for fairness from Beijing.
The government is also examining an agreement by Chinese conglomerate HNA Group to buy a stake in SkyBridge Capital LLC the firm founded by Anthony Scaramucci who was briefly White House communications director.
China the largest chip market has been on the hunt for acquisitions in the field as it looks to build a domestic supply and rely less on imports as the billion global semiconductor industry undergoes its biggest wave of consolidation.
by Alpha | Sep 11, 2017 | Pre-Market
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3. ATI:Allegheny Technologies $ATI was upgraded to ‘Buy from ‘Hold’ at Bank of America/Merrill Lynch
8. TAHO:Stupid shorts – Tahoe Resources $TAHO Says Guatemalan Supreme Court Reinstated Escobal License
14. HRTG:$HRTG Big day for insurers on tap as Irma less than feared.
15. RXDX:Laden $RXDX is positioned to begin a pivotal Phase II study in NSCLC non-KIF5B-RET fusions. Reiterate Buy and $20.25 PT.
Trending News Headlines
1. Stemline Therapeutics Presents SL-801 Phase 1 Data at ESMO 2017
NEW YORK, Sept. 11, 2017 (GLOBE NEWSWIRE) — Stemline Therapeutics, Inc. (Nasdaq: STML ), a clinical-stage biopharmaceutical company developing novel therapeutics for difficult to treat cancers, announced the presentation of clinical data from the ongoing SL-801 Phase 1 trial in patients with advanced solid tumors. The data were presented at the European Society of Medical Oncology (ESMO) Annual Congress 2017 in Madrid, Spain.
2. Tesla boosts range for some vehicles in Florida to escape Irma
As Hurricane Irma was bearing down on Florida, Tesla Inc. sent a free software update extending the battery capacity of some of its vehicles, giving those owners extra range to flee the looming storm.
3. Almost everything Apple is set to announce Tuesday, including iPhone X, was leaked this weekend
Apple is expected to unveil the iPhone 8, iPhone 8 Plus and iPhone X on Tuesday, almost all of the details were spilled over the weekend.
4. Early movers: HCI, UVE, HRTG, XL, RE, JNJ, PPC, TEVA, AAPL & more
Some of the names on the move ahead of the open.
5. Viking Therapeutics Announces Results of Gene Expression Analysis from In Vivo Study of VK2809 in Non-Alcoholic Steatohepatitis (NASH)
SAN DIEGO, Sept. 11, 2017 /PRNewswire/ — Viking Therapeutics, Inc. (“Viking”) (NASDAQ: VKTX), a clinical-stage…
6. Investor euphoria for Incyte’s cancer immunotherapy is hard to rationalize
Incyte’s not-yet-approved cancer drug accounts for $10 billion of the company’s value. A close look at the data raises major questions about its worth.
Technology News
Nearby an overturned couch pokes out from an elevator shaft a leftover from the widespread departures that followed Hillary Clinton defeat.
After word spread of the Russian hack the DNC tech team was widely criticized for failing to heed warnings from the Federal Bureau of Investigation that the party was under attack.
I was in a hotel room in San Francisco and I was just like I called my friend Alexander Macgillivray who used to be deputy CTO of the United States and said can someone like me even do in this world He laid out two or three options.
Details from the leaked iOS golden master keep on coming today with discovering references in the firmware to potential new Apple Watch case colors which might be announced on Tuesday September.
Mockup for a Blush Gold iPhone via Benjamin Geskin The Aluminum Blush Gold Apple Watch lends further credence to similar nomenclature we been hearing about a new color coming to the iPhone line.
Still the company traditionally updates the Apple Watch with new collections colors casing styles and bands at these events so it likely the Apple Watch Series will have some kind of new colors for users to choose from.
Krikorian who ran cars program after serving as vice president of engineering has instructed staffers at the DNC to use Signal instead of SMS until he and other recent hires on his team finish a internal review of the technology and security needs including a more standardized move to encrypted messaging that could extend beyond the building to local state parties.
Krikorian casts his ongoing review as part an initial push to the ship with In the he said about the better and more frequent cybersecurity education simulated phishing attacks verification moving the email management to cloud services assessing their threat model.
One year after the DNC email hack a cyberattack that revealed an unfair bias against Bernie Sanders and made the party committee a source of fierce dissatisfaction and distrust among progressives Krikorian is also hoping for a larger culture change inside headquarters.
The forthcoming Apple Watch Sport will apparently come in a new Blush Gold color over its aluminum material digging in the firmware by has revealed.
Pricing is not yet known but there have been indications that some carriers might offer a free month of service to entice users to try the LTE connectivity.
All will be revealed this Tuesday at Pacific Eastern at the Apple Park Steve Jobs Theater where our reporter Daniel Eran Dilger will be on site with exclusive news and analysis.
People who can file a regulatory action while being emotionless about it are terrifying because they suggest that their day job is administrator for a hospital that very comfortable with pushing papers around government agencies and that they will remember deadlines keep copious records and consult with other professionals where appropriate.
Blindingly obvious errors lead to punitive damages and very incensed regulators so even if the CRA has a way for a trade line checked in our web application and shocker the database says what we said it said click here to generate form they will not trust their usual process to do it.
They will likely not sue on your behalf they might depending on temperament and your paper trail either send a letter that you could have sent but which is signed Dangerous Professional Attorney At Law or perhaps file suit to get the attention of the legal department at the CRA or bank.
PARIS Reuters France Germany Italy and Spain want digital multinationals like Amazon and Google to be taxed in Europe based on their revenues rather than only profits as now their finance ministers said in a joint letter.
France is leading a push to clamp down on the taxation of such companies but has found support from other countries also frustrated at the low tax they receive under current international rules.
The letter signed by French Finance Minister Bruno Le Maire Wolfgang Schaeuble of Germany Padoan of Italy and Luis de Guindos was addressed to the Estonian presidency with the executive Commission in copy.
Zello is used almost exactly like a walkie talkie except it relies on wifi and cell service so it can support big groups of people in dispersed locations.
With the crush of new users and emergency situations most of the Zello team is working long days either maintaining capacity or helping with customer support Moore said.
Still with traditional communications systems threatened by the storm Zello stands to play a critical role once again as Irma makes its approach toward Florida.
Shelly Jones gets help carrying her dogs out of the boat belonging to Josh Mtanyos with the Cajun Navy as they were rescued as heavy rains from Tropical Storm Harvey continued filling the the San Jacinto River just north of Tuesday in Houston.
Shelly Jones gets help carrying her dogs out of the boat belonging to Josh Mtanyos with the Cajun Navy as they were rescued as heavy rains from Tropical Storm Harvey continued filling the the San Jacinto River just north of Tuesday in Houston.
Shelly Jones gets help carrying her dogs out of the boat belonging to Josh Mtanyos with the Cajun Navy as they were rescued as heavy rains from Tropical Storm Harvey continued filling the the San Jacinto River just north of Tuesday in Houston.
ET authorities plan to shut down domestic bitcoin exchanges delivering a final blow to a industry of commercial trading for virtual currencies which took off inside the mainland four years ago.
The central bank has led a draft of instructions that would ban Chinese platforms from providing virtual currency trading services according to people familiar with the matter.
