$AAPL: Pacific Crest downgrades Apple on weaker iPhone sales expectation | $LOXO, $HMNY, $BLUE, $BMY,

1. LOXO: $LOXO Loxo Oncology jumps premarket on news of positive cancer drug trial – MW

2. HMNY:  $HMNY Helios & Matheson Analytics and RedZone Announce RedZone Has Acquired All the Assets of Trendit

3. PBYI:  $PBYI Puma Biotech Reports Positive PB272 Ph II Data for Metastatic Breast Cancer w Brain Metastases

4. DHI, FOR:  $FOR Homebuilder D.R. Horton $DHI offers to buy 75 percent of Forestar for $520M – Reuters

5. GIMO:  $GIMO Exclusive: Elliott target Gigamon prepares to explore a sale – sources – SI

6. TGTX:  $TGTX TG Therapeutics stock rises on positive late-stage cancer trial results – MW

7. RNN:  $RNN Rexahn Pharma Delivers Prelimy Efficacy Data from Ongoing Ph IIa Metastatic Bladder Cancer Trial

8. BCRX:  $BCRX BioCryst Announces RAPIVAB® Pediatric sNDA Acceptance – GN

9. BLUE, CELG:  $BLUE Bluebird, Celgene $CELG CAR-T Keeps Multiple Myeloma Patients Relapse Free – Adam Feuerstein

10. PGLC:  $PGLC Pershing Gold Announces Positive Preliminary Feasibility Study for Relief Canyon – PRN

11. SRRA:  $SRRA Sierra Oncology shares jump premarket on news of positive early-stage cancer drug trials – MW

12. HTGM:  $HTGM HTG Molecular Diagnostics Expands IVD Agreement W Illumina to Increase Number of Test Kits – GN

13. ARRY, LOXO:  $ARRY Array Biopharma Gains in Sympathy with Loxo Oncology $LOXO – SI

14. P, SIRI, VZ:  $P Verizon $VZ mulling Pandora investment if SiriusXM $SIRI deal fails – NYPost

15. SOHU:  $SOHU Provides Updated Guidance for Second Quarter 2017 – PRN

16. CYOU:  $CYOU Updates Q2 Guidance – SI

17. INCY:  $INCY ASCO data show ‘deepening response’ to Incyte’s epacadostat/Keytruda combo – Fierce Biotech

18. TSRO:  $TSRO TESARO Provides Business and Pipeline Update at ASCO Investor Briefing – SI

19. TPX:  $TPX Tempur Sealy Provides Business Update – PRN

20. AZN:  $AZN AstraZeneca’s Lynparza Slows Spread of Inherited Breast Cancer – BBG

21. ABBV:  $ABBV AbbVie Presents New Data on IMBRUVICA – SI

22. AGIO: $AGIO Agios Presents Phase 1 Data from Dose-Escalation & Expansion Cohorts of AG-120 – GN

23. FPRX: $FPRX Five Prime Therapeutics Reports on Cabiralizumab & Single-Agent FPA144 at ASCO Meetings

24. AKBA, FGEN: $AKBA Akebia Prevails in Two Additional European Patent Disputes $FGEN

25. EGLT: $EGLT Egalet Receives New U.S. Patent for Guardian Technology – SI

26. GLYC: $GLYC GlycoMimetics Presents Updated Data from Ongoing Phase 1/2 Clinical Trial of GMI-1271 – SI

27. JKS:  $JKS JinkoSolar Announces First Quarter 2017 Financial Results – PRN

28. HLF:  $HLF Herbalife to lower its quarterly sales outlook: report – MW

29. INSY:  $INSY Insys Therapeutics, Inc. Releases Statement on Its Ongoing Mission – GN

30. NLNK:  $NLNK NewLink Genetics Phase 2 trial of Indoximod in Combination with Taxane Doesn’t Meet Endpoints

31. CYTR:  $CYTR CytRx set for down day on disappointing OS data on aldoxorubicin – SA

1. EBAY:Credit Suisse Upgrades eBay $EBAY to Outperform; Multiple Paths to Value Creation

2. GPS:Gap up more than 1% after upgrade

3. LOXO:$LOXO upgraded to Buy from Neutral at Citi. PT $86 from $45

4. NAV:#Navistar upgraded from neutral to outperform at Baird. Price target raised by $1 to $33. $NAV 6/2 close: 25.75…

5. XOM:$XOM upgraded to Sector Outperform @ Scotia Howard Weil interesting as XOM breaking Sup at $80 with room to $75-77 on downside

6. YELP:Bank of America Merrill Lynch upgrades Yelp; shares up 2.6%

1. AAPL:Pacific Crest downgrades Apple on weaker iPhone sales expectation

2. ECYT:Wedbush downgrades $ecyt from outperform to neutral & $2 PT.

3. PRGO:RBC softens view on Perrigo, downgrades to Underperform; shares slip 3% premarket

1. JKS:$JKS reports FQ1 earnings of 36c EPS and $839.26M Revs –

1. PBYI:Puma Biotechnology FDA Live Blog $PBYI #biotech

2. BLUE:$BLUE $CELG Announce Updated Clinical Results From Study of Bb2121 Anti-BCMA CAR T Cell Therapy #ASCO17

3. JUNO:$JUNO JCAR017 50% CR rate at 3 months in DLBCL. They’re back. #ASCO17

4. KITE:Juno Therapeutics Mounts CAR-T Comeback With Strong Lymphoma Study Results —> $KITE $NVS #ASCO17

5. TGTX:$TGTX little pressure on shorts today

6. LOXO:$LOXO upgraded to Buy from Neutral at Citi. PT $86 from $45

7. GLYC:$GLYC presents encouraging data from Ph1/2 trial of GMI-1271 in Patients with Acute Myeloid Leukemia at ASCO

8. BMY:Bristol-Myers Squibb’s Opdivo, Yervoy put the brakes on mesothelioma in phase 2 $BMY #pharma #ASCO17

9. PFE:Pfizer’s two-time loser dacomitinib finally wins in phase 3 against AstraZeneca’s Iressa $PFE $AZN #pharma #ASCO17

10. DVAX:Dynavax up 26% premarket on positive SD-101 results #premarket $DVAX

11. INCY:This Enzyme Is the New Focus for Cancer Treatment #IDO $INCY $MRK $NLNK #ASCO17

12. JNJ:Old prostate cancer CW: Xtandi > Zytiga. #ASCO17 CW: Zytiga > Xtandi $JNJ $PFE David Hung: ‍♂️

1. Press Release | Blueprint Medicines

2. Aurinia Presents Additional Data from Phase Iib Aura-Lv Study, Demonstrating Stable Renal Function and Blood Pressure without Electrolyte Complications Through 48 Weeks

3. Akebia Prevails in Two Additional European Patent Disputes

4. APHINITY trial (BIG 4-11): A randomized comparison of chemotherapy (C) plus trastuzumab (T) plus placebo (Pla) versus chemotherapy plus trastuzumab (T) plus pertuzumab (P) as adjuvant therapy in patients (pts) with HER2-positive early breast cancer (EBC). | 2017 ASCO Annual Meeting Abstracts

5. Andy Biotech on Twitter

6. Insys Therapeutics, Inc. Releases Statement on Its Ongoing Mission

7. Clinical Trial Data for Combination of Epacadostat and Opdivo® (nivolumab) Demonstrate Durable Clinical Responses in Patients with Melanoma and Head and Neck Cancer

8. What to expect from WWDC 2017

9. Press Release | Investor Relations | Bluebird Bio

10. Oil prices dip on fears Middle East spat could harm OPEC cuts

11. bluebird bio and Celgene Corporation Announce Updated Clinical Results from Ongoing First-in-Human Multicenter Study of bb2121 Anti-BCMA CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma at ASCO Annual Meeting

12. Bristol-Myers Squibb’s Opdivo, Yervoy put the brakes on mesothelioma in phase 2 | FiercePharma

13. European Patent Office Maintains FibroGen Patent Relating to Hypoxia-Inducible Factor (HIF) Prolyl Hydroxylase Inhibitor Technology

1. The open source community’s diversity problem could make the larger tech industry’s entrenched imbalances worse

Where free collaborative software projects were once the flags flown by indie developers bucking corporate computing today even companies like Exxon Mobil and Wells Fargo are releasing their own open source tools.

Beyond the consequences for open source projects themselves the diversity problem could actually make the larger tech entrenched imbalances worse.

One thing many respondents said drives them away from open source projects are negative interactions such as rudeness stereotyping the more extreme end of the and outright harassment.

2. The free software movement is for everyone. Wow, do we have a lot of work to do:

Where free collaborative software projects were once the flags flown by indie developers bucking corporate computing today even companies like Exxon Mobil and Wells Fargo are releasing their own open source tools.

Beyond the consequences for open source projects themselves the diversity problem could actually make the larger tech entrenched imbalances worse.

One thing many respondents said drives them away from open source projects are negative interactions such as rudeness stereotyping the more extreme end of the and outright harassment.

3. “What Really Happened with Vista” — by Eng/Tech Master Terry Crowley

The number of layers is carefully constrained so the mobile graphics processor can achieve the fast frame rates needed for smooth animation and user interaction with very low power usage.

The challenge was that replacing the file system with a completely new implementation that provides major new functionality while at the same time appearing essentially unchanged to the vast array of existing software is an incredibly daunting task.

Especially because key Windows core engineering was busy with other efforts security and WinFS was built as a component that would sit on the side and provide additional functionality for searching and rich queries.

4. This insane 25 minute(!) read details everything that went wrong with Windows Vista

The number of layers is carefully constrained so the mobile graphics processor can achieve the fast frame rates needed for smooth animation and user interaction with very low power usage.

The challenge was that replacing the file system with a completely new implementation that provides major new functionality while at the same time appearing essentially unchanged to the vast array of existing software is an incredibly daunting task.

Especially because key Windows core engineering was busy with other efforts security and WinFS was built as a component that would sit on the side and provide additional functionality for searching and rich queries.

5. i’m kind of disappointed in all of us for not anticipating that thiel would find a way to profit off the border wall

In May they posed for photos at a cosplay conference in Japan dressed as a character from the game Metal Gear Solid complete with identical bikini tops ripped black tights and ammunition belts.

While Luckey became a tech icon for reviving interest in virtual reality his politics burst into view in September when The Daily Beast published an article saying he had quietly funded a nonprofit Nimble America.

Those familiar with the plan say Luckey believes his system which can be mounted on telephone poles can be built far more cost effectively than proposed wall on the Mexican border and with fewer obstacles from landowners.

6. New by me: Bitcoin Firm Coinbase Seeks New Funds at $1 Billion Valuation

ET Interest in bitcoin has been skyrocketing again as the price of the digital currency has hit new highs.

That only helps bitcoin startups in the eyes of investors.

One of these startups Coinbase is in talks with potential investors on a new round of funding at a valuation of more than billion according to people familiar with the matter.

7. “the never-lose structure of modern executive compensation packages”

When early efforts to turn around business and spin off the Alibaba shares failed to bear fruit another hedge fund manager Jeffrey Smith of Starboard Value led a campaign to push for her ouster.

Mayer has come under more scrutiny than most Silicon Valley chief executives in part because of the Superwoman image she cultivated in an industry dominated by men the computer scientist and tireless manager who still wrote code for fun while raising three young children and looking stylish in Oscar de la Renta.

The DNA and technology were built around its original identity as a web portal a powerful position in the early but increasingly outmoded in the mobile era as apps and phone platforms like iOS and Android became the gateways to the internet.

8. Palmer Luckey, founder of Oculus, is back with a defense startup that wants to build a virtual border wall. My scoop

In May they posed for photos at a cosplay conference in Japan dressed as a character from the game Metal Gear Solid complete with identical bikini tops ripped black tights and ammunition belts.

While Luckey became a tech icon for reviving interest in virtual reality his politics burst into view in September when The Daily Beast published an article saying he had quietly funded a nonprofit Nimble America.

Those familiar with the plan say Luckey believes his system which can be mounted on telephone poles can be built far more cost effectively than proposed wall on the Mexican border and with fewer obstacles from landowners.

9. Positive step toward expanding the main point of interest/narrative away from the game itself & more to the player

One of challenges is to balance attracting outside investors with its interest in supporting existing teams that have helped grow League of Legends to where it is today.

too risky said Jace Hall the chief executive officer of Echo Fox which currently competes in League Championship Series LCS.

And in league the rich get richer Teams that perform better will receive a larger share of revenue which will come largely from the million streaming deal it signed with BAMTech last year.

10. “If she were an ugly man, she’d be a hero,” one recruiter said

When early efforts to turn around business and spin off the Alibaba shares failed to bear fruit another hedge fund manager Jeffrey Smith of Starboard Value led a campaign to push for her ouster.

Mayer has come under more scrutiny than most Silicon Valley chief executives in part because of the Superwoman image she cultivated in an industry dominated by men the computer scientist and tireless manager who still wrote code for fun while raising three young children and looking stylish in Oscar de la Renta.

The DNA and technology were built around its original identity as a web portal a powerful position in the early but increasingly outmoded in the mobile era as apps and phone platforms like iOS and Android became the gateways to the internet.